益智治呆方联合吡拉西坦治疗老年痴呆症的临床研究  

Clinical efficacy of good intelligence prescription combined piracetam on Alzheimer's disease patients

作　　者：赵翠霞[1] 阿衣努尔.木合买提巴克 万智[1] 江钰[1] 省格丽[1] 

机构地区：[1]新疆医科大学附属中医医院老年病科,乌鲁木齐830000 [2]新疆医科大学附属中医医院大十字分部,乌鲁木齐830000

出　　处：《中国临床药理学杂志》2015年第15期1506-1508,共3页The Chinese Journal of Clinical Pharmacology

基　　金：新疆维吾尔自治区自然科学基金资助项目(2015200C152)

摘　　要：目的评价益智治呆方联合吡拉西坦治疗老年痴呆症的临床疗效及其对记忆力的影响。方法 114例老年痴呆症患者随机分为试验组57例和对照组57例。对照组口服吡拉西坦片0.8~1.6 g,每天4次;试验组在对照组的基础上服用益智治呆方,每天1剂,分2次服用,2组均4周为1个疗程。治疗前和连续治疗3个月后对其进行简易智能量表（MMSE）和巴氏指数（BI）评定,并对患者进行认知功能、记忆力和Blessed痴呆量表评估。观察2组患者的临床疗效和不良反应发生情况。结果试验组的总有效率为94.74%,显著高于对照组的63.15%（P〈0.05）。治疗后,试验组的MMSE和BI评分分别为（22.2±2.3）,（85.8±5.9）,显著高于对照组的（17.5±2.1）,（74.9±5.7）（P〈0.05）。治疗后,试验组的认知功能、词汇记忆均显著高于对照组（P〈0.05）。试验组Blessed痴呆量表评分（4.6±2.4）低于对照组患者评分（5.8±2.5）。试验组不良反应发生率为7.01%,显著低于对照组的28.07%（P〈0.05）。结论益智治呆方联合吡拉西坦可有效改善老年痴呆症患者临床症状,提高患者记忆力和生活能力,安全性高。Objective To observe and study the efficacy and the impact on memory of alzheimer＇s disease patients treated with perception of enhancing intelligence and treating dementia. Methods A total of 114 cases of alzheimer＇s patients were randomly divided into treatment group （57 cases） and control group （57 cases）. Patients in control group were treated with piraeetam, oral 0. 8 - 1.6 g, 4 times a day. Patients in treatment group were taken perception of enhancing intelligence and treating dementia on the basis of control group, 2 times a day, 4 weeks for a course of treatment. Before and after three months treatment, MMSE, BI, and cognitive function, memory and Blessed dementia scale were assess. Clinical efficacy and adverse reactions of the two groups were observed. Results Total effective rate in treatment group was 94.74%, significantly higher than that in control group, which was 63.15% （P〈0.05）. After treatment, MMSE score （17.5 ±2. 1） and BI score （74. 9 ±5.7） in control group were significantly lower than that in treatment group, which were （22.2 ±2.3）, （85.8 ±5.9）, （P 〈 0. 05 ）. After treatment, cognitive function, vocabulary and memory in treatment group were significantly higher than that in control group. The Blessed dementia scale score in treatment group （4.6 ±2.4） was lower than that in control group （5.8 ±2.5 ）. The incidence of adverse reactions in treatment group（7.01% ）, was lower than that in control group（28. intelligence and treating dementia combined piracetam can skills of alzheimer＇s patients. 07%, P 〈 0. 05 ）. Conclusion Perception of enhancing effectively improve the clinical symptoms, memory and life

关 键 词：益智治呆方 老年痴呆症 吡拉西坦 记忆力 

分 类 号：R749.1[医药卫生—神经病学与精神病学] R285[医药卫生—临床医学]