三梗降气汤治疗脾虚气逆型胃食管反流病临床观察  

Clinical Efficacy of Sangeng Jiangqi Decoction in Treatment of Gastroesophageal Reflux with Spleen Deficiency and Reversed Flow of Qi

作　　者：林俊儒[1] 柳文[1] 刘竹轩 华云玮[1] 

机构地区：[1]上海中医药大学附属龙华医院消化内科,上海200071

出　　处：《安徽中医药大学学报》2015年第4期32-36,共5页Journal of Anhui University of Chinese Medicine

摘　　要：目的观察三梗降气汤治疗脾虚气逆型胃食管反流病的疗效及其对生活质量的影响。方法将121例脾虚气逆型胃食管反流病患者随机分为治疗组与对照组。治疗组61例予三梗降气汤治疗,对照组60例予奥美拉唑加莫沙必利治疗,疗程12周。观察两组临床疗效,治疗前后分别观察两组单个症状积分,分别采用36条目简明健康量表(36-item short-form health survey,SF-36)和胃食管反流病生活质量量表(quality of life questionnaire for gastroesophageal reflux disease,GERD-QOL)评价患者的生活质量。结果治疗组有4例脱落,1例退出;对照组有5例脱落,2例退出。两组临床疗效比较,差异无统计学意义(P>0.05)。治疗组在改善神疲乏力、胃脘胀满方面明显优于对照组(P<0.05)。在改善SF-36量表的精力、社会功能、精神健康3个维度方面,以及在改善GERD-QOL量表的总分及其心理健康维度方面,治疗组明显优于对照组(P<0.05)。结论三梗降气汤能有效改善脾虚气逆型胃食管反流病的临床症状,并能提高患者生活质量。Objective To investigate the efficacy of Sangeng sophageal reflux with spleen deficiency and reversed flow of Methods A total of 121 gastroesophageal reflux patients qi were randomly divided into treatment group （n=61） and Jiangqi Decoction in the treatment of gastroe- qi and its impact on patients＇ quality of life. with spleen deficiency and reversed flow of control group （n=60）. The treatment group received Sangeng Jiangqi Decoction, while the control group received omeprazole combined with mosa- pride. The course of treatment was 12 weeks for both groups. The treatment outcomes of the two groups were evaluated; before and after treatment, the scores of single symptoms were determined, and the 36-Item Short-Form Health Survey （SF-36） and Quality of Life Questionnaire for Gastroesophageal Reflux Disease （GERD-QOL） were used to evaluate the patients＇ quality of life. Results In the treatment group, 4 cases were lost, and 1 case quit; in the control group, 5 cases were lost, and 2 cases quit. There was no significant difference in treatment outcome between the two groups （P〉0.05）. The treatment group had significantly more improvements in fatigue/weakness and gastric distension （P〈0.05）. In addition, the treatment group had significantly more improvements in the scores of social function, vitality, mental health in SF-36 and the total score and mental health score of GERD-QOL than the control group （P〈0.05）. Conclusion For gastroesophageal reflux patients with spleen deficiency and reversed flow of qi, Sangeng Jiangqi Decoction can effectively relieve clinical symptoms and improve their quality of life.

关 键 词：胃食管反流病 三梗降气汤 生活质量 

分 类 号：R57[医药卫生—消化系统]