全脑放疗联合与不联合立体定向放疗治疗脑转移瘤疗效对比  

Effects of whole brain radiotherapy with and without stereotactic radiotherapy on metastatic encephaloma

作　　者：王刚[1] 刘旭[1] 李宏伟[1] 杨战国[1] 陈公安[1] 

机构地区：[1]郑州市第三人民医院放疗科,450000

出　　处：《中国实用医刊》2015年第16期52-53,共2页Chinese Journal of Practical Medicine

摘　　要：目的：对全脑放疗联合与不联合立体定向放疗在脑转移瘤中的治疗效果予以对比分析。方法随机选取郑州市第三人民医院收治的脑转移瘤患者42例，将其均分为两组，分别作为对照组与观察组，对照组应用全脑放疗治疗，观察组实施全脑放疗与立体定向放疗相结合的方法治疗，对两组患者的生存期及致死率进行对比分析。结果观察组脑转移致死率为9.5%，对照组为57.1%，差异有统计学意义（P ﹤0.05）。观察组中位生存时间为6.3个月，对照组为4.1个月，差异有统计学意义（P ﹤0.05）。结论在脑转移瘤患者的治疗中，应用立体定位放疗与全脑放疗相结合的治疗方法，与单纯全脑放疗疗法相比具有良好的治疗效果，能够有效降低患者的致死率，提高患者的中位生存时间，值得在临床应用中推广。Objective To analyze the effects of whole brain radiotherapy with and without stereotactic radiotherapy on metastatic encephaloma. Methods Forty-two patients with metastatic encephaloma were randomly selected,the patients were divided into two groups,as the control group and the observation group,patients in the control group were given whole brain radiotherapy treatment,patients in the observation group were given stereotactic radiotherapy combined with whole brain radiotherapy. The survival and mortality rates of the two groups were analyzed. Results The mortality rate was 9. 5% in the observation group,while the mortality rate in the control group was up to 57. 1% ,the difference was significant（P ﹤ 0. 05）. The median survival time was 6. 3 months in the observation group,and was 4. 1 months in the control group,the difference was significant（P ﹤ 0. 05）. Conclusions In the treatment of patients with metastatic encephaloma, the stereotactic radiotherapy combined with whole brain radiation therapy,compared with whole brain radiation therapy alone therapy,has good therapeutic effect,can effectively reduce the mortality rate of patients and improve the median survival time,so is worthy of clinical application.

关 键 词：全脑放疗 立体定位放疗联合全脑放疗 脑转移瘤 疗效 

分 类 号：R730.55[医药卫生—肿瘤]