酪蛋白磷酸多肽-无定形磷酸钙在固定正畸过程中预防釉质脱矿的临床研究  

Clinical research of CPP-ACP in the prevention of enamel demineralization during fixed orthodontic

作　　者：唐璐[1] 杨四维[2] 庞兰[1] 李宇[1] 

机构地区：[1]成都大学附属医院口腔科,成都610081 [2]泸州医学院附属口腔医院口腔正畸科,泸州646000

出　　处：《重庆医科大学学报》2015年第6期881-884,共4页Journal of Chongqing Medical University

基　　金：四川省卫生厅科研课题资助项目(编号:110091)

摘　　要：目的:研究酪蛋白磷酸多肽-无定形磷酸钙(casein phosphopeptide-amorphic calcium phosphate,CPP-ACP,商品名GC护牙素)在固定正畸过程中预防釉质脱矿的临床效果。方法:经签字同意进入实验的固定正畸患者60例,随机分为A、B、C 3组,每组20名。A组:空白对照组。B组:氟化泡沫组。C组:CPP-ACP组。3组患者从治疗起始,每月均使用Canon60D专业相机拍摄1次牙照片,共13次,观察时间为13个月。临床检测指标为牙面是否出现新增的白垩色斑点或龋洞,计算牙釉质脱矿指数(enamel demineralization index,EDI)。采用SPSS18.0软件包进行统计分析。结果:(1)从12次牙釉质脱矿变化看,A、B、C3组的牙釉质脱矿率都随着时间的延长而增高;(2)3种不同处理方式EDI差异有统计学意义,两两比较发现:A、C 2组高于B组,A、C 2组间差异无统计学意义。结论:(1)固定正畸所引起的牙釉质脱矿的发生率和严重程度与正畸时间呈正相关。(2)固定正畸患者,定期使用氟化泡沫能够有效减少釉质脱矿的发生。(3)接受固定矫治器治疗的正畸患者,定期使用护牙素是预防釉质脱矿的一种安全有效措施。Objective：To observe the clinical results of using Casein phosphopeptide-amorphic calcium phosphate（CPP-ACP）for preventing enamel demineralization in the fixed orthodontic process. Methods：Totally 60 volunteers who were undergoing fixed orthodontics in this study were randomly divided into 3 groups,20 volunteers in each group. Group A was control group and received routine dental health care. Group B appended fluoride foam based on group A while receiving routine dental health care. Group C appended CPP-ACP based on group A. From the start of treatments,their occlusion pictures were taken per month,totally 13 times a year. The clinical test index was calculated to see whether new plaque or caries appeared on the tooth surfaces,meanwhile the enamel demineralization index（EDI）was calculated. The SPSS 18.0 pack program was used for statistical analysis. Rank sum test was used to determine the numerical variable data; categorical data were determined by using the chi-square test. Results：（1）From the change of enamel demineralization in 3 groups,the EDI was increasing as time went on（χ2A=259.615,P=0.000,χ2B=190.416,P=0.000,χ2C=207.512,P=0.000）;（2）There were statistical differences in EDI among three groups. EDI was higher in groups A,C than in group B,while there was no statistical significance between group A and group C. Conclusion：The EDI and enamel demineralization damage degree has a positive correlation with the time spent in fixed appliance. Fluoride foam treatment can reduce EDI in patients with orthodontics. CPP-ACP is the effective and safety way to prevent enamel demineralization among volunteers.

关 键 词：固定矫治 釉质脱矿 氟化泡沫 酪蛋白磷酸多肽-无定形磷酸钙 

分 类 号：R783.5[医药卫生—口腔医学]