半乳凝素-3和微小RNA-21在非小细胞肺癌中的表达和临床意义  

The expression level and clinical significance of Galectin-3 and miRNA-21 in non-small-cell lung carcinoma

作　　者：易震南[1] 伍俊[1] 黄仁清[1] 黎东明[1] 张绪超[2] 

机构地区：[1]广东医学院附属医院呼吸内科,广东湛江524001 [2]广东省人民医院/广东省肺癌研究所,广州510030

出　　处：《重庆医学》2015年第23期3198-3200,3203,共4页Chongqing medicine

基　　金：广东省医学科研基金项目(A2013431)

摘　　要：目的研究半乳凝素-3(Galectin-3)和微小RNA-21(miRNA-21)在非小细胞肺癌(NSCLC)组织中的表达和临床意义。方法选取150例NSCLC患者作为肺癌组,同一时期来该院进行治疗的150例肺部良性病变患者作为对照组。比较两组患者的Galectin-3和miRNA-21的表达水平,分析它们与患者临床特征的相关性。结果肺癌组患者的Galectin-3为6.75±2.38,miRNA-21为5.91±1.59;肺癌组患者的Galectin-3为1.12±0.29,miRNA-21为0.97±0.17,差异具有统计学意义(P<0.05)。Galectin-3的水平与临床分期、分化程度、肿瘤直径、淋巴结转移和患者的无进展生存期(PFS)和总生存期(OS)有明显相关性(P<0.05)。miRNA-21水平与临床分期、分化程度、肿瘤直径和患者的PFS和OS有明显的相关性(P<0.05)。Galectin-3敏感度为90.20%,特异度为70.69%;miRNA-21的敏感度为88.24%,特异度为69.97%,差异无统计学意义(P>0.05)。结论 Galectin-3和miRNA-21的表达水平在NSCLC的诊断和预后判断中具有一定的应用价值。Objective To study the expression level and clinical significance of Galectin-3and miRNA-21 in non-small-cell lung carcinoma（NSCLC）.Methods One hundred and fifty patients with NSCLC were chosen as cancer group,and 150 patients with benign pulmonary diseases were chosen as control group.The expression level of Galectin-3and that of miRNA-21 between two groups were compared,and the relevance between expression level of Galectin-3and that of miRNA-21 and clinical feature were analysed.Results In cancer group,the expression level of Galectin-3was 6.75±2.38,and that of control group was 1.12±0.29;the expression level of miRNA-21 was 5.91±1.59,and that of control group was 0.97±0.17,and the difference between two groups had statistical significance（P〈0.05）.The relevance between expression level of Galectin-3and stage,differentiation,lymphatic metastasis,diameter of carcinoma and PFS,OS of patients had statistical significance（P〈0.05）.The relevance between expression level of miRNA-21 and stage,differentiation,diameter of carcinoma and PFS,OS of patients had statistical significance（P〈0.05）.In the diagnosis of NSCLC,the sensitivity of the expression level of Galectin-3was 90.20%,and its specificity was 70.69%,while the sensitivity of expression level of miRNA-21 was 88.24% and its specificity was 69.97%.The difference between the diagnostic value of Galectin-3and that of miRNA-21 had no statistical significance（P〉0.05）.Conclusion The expression level of Galectin-3and that of miRNA-21 can be applied in the diagnosis and prognosis of non-small-cell lung carcinoma.

关 键 词：非小细胞肺癌 半乳糖凝集素类3 微RNAS 

分 类 号：R734.2[医药卫生—肿瘤]