血清甲状腺激素与抑郁障碍的相关性分析  

A study of correlation between the serum thyroxin and depressive symptoms of patients with depression

作　　者：贾杰[1] 王姗[1] 刘显阳[1] 党伟[1] 王赞利[1] 陈英[1] 钟意娟[1] 

机构地区：[1]陕西省西安市精神卫生中心,710061

出　　处：《精神医学杂志》2015年第3期171-174,共4页Journal of Psychiatry

基　　金：陕西省西安市卫生局科研项目(编号:J2011044)

摘　　要：目的探讨血清甲状腺激素水平与抑郁障碍的相关性。方法选取149例单相抑郁障碍患者(单相抑郁障碍组)、40例双相抑郁障碍患者(双相抑郁障碍组)和40名健康者(对照组)为研究对象,检测血清三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)等血清甲状腺激素水平指标。再对单相抑郁组进行3个月治疗随访,根据汉密尔顿抑郁量表(HMAD)评分结果将其分为临床缓解单相组和临床未缓解单相组,再进行血清甲状腺激素水平和HMAD评分。结果单相抑郁障碍组和双相抑郁障碍组的TSH水平均高于对照组(P<0.05)。治疗前临床缓解单相组的TSH高于对照组(P<0.05)。治疗后临床缓解单相组的TSH高于对照组(P<0.05),而FT3、FT4低于对照组(P<0.05)。临床缓解单相组治疗后TT3高于治疗前(P<0.05),而TT4、FT4则显著低于治疗前(P<0.05)。治疗前、后,临床未缓解单相组的TSH均高于对照组(P<0.05)。临床未缓解单相组治疗后TSH低于治疗前(P<0.05)。治疗前临床缓解单相组的FT3低于临床未缓解单相组(P<0.05)。治疗后临床缓解单相组的TT4、FT3低于临床未缓解单相组(P<0.05)。结论抑郁障碍患者存在甲状腺激素水平的异常,其症状改善与甲状腺激素水平变化有一定关系。Objective To explore the correlation between the serum thyroxin and depressive symptoms of patients with depression. Methods A total of 149 patients with unipolar depression （UD group）, 40 patients with bipolar depression （BD group） and 40 healthy people （control group） were selected and examined for the serum levels of TT3, TT4, TSH, FT3 and FT4. The patients in UD group were treated with antidepressants for 3 months and divided into the remission UD group and the unremission UD group according to the scores of HAMD. The patients in UD group were examined for the HAMD and the serum levels of Tl3, TI＇4, TSH, FT3 and FT4 before and after treatment. Results The serum levels of TSH in UD group and BD group were all significantly higher than those in control group （ P 〈 0.05 ）. Before treatment, the serum level of TSH in the remission UD group was significantly higher than that in control group （ P 〈 O. 05 ）. After treatment, the serum levels of TSH in the remission UD group were significantly higher and FT3, FT4 significantly lower than those in control group （ P 〈 0.05 ）. The serum levels of TI3 in the remission UD group after treatment were significantly higher and 334, FT4 significantly lower than those before treatment （ P 〈 0.05 ）. Before and after treatment, the serum levels of TSH in the unremission UD group were all significantly higher than those in control group （ P 〈 0.05 ）. The serum levels of TSH in the unremission UD group after treatment were significantly lower than those before treatment （ P 〈 0.05 ）. Before treatment, the serum level of FI3 in the remission UD group was significantly lower than that in the unremission UD group （P 〈 0.05 ）. After treatment, the serum levels of 334, FF3 in the remission UD group were significantly lower than those in the unremission UD group （ P 〈 0.05 ）. Conclusion There is the abnormal level of serum thyroxin in patients with depression and the correlation between the change of serum thyroxin and improve

关 键 词：抑郁障碍 三碘甲状腺原氨酸 总甲状腺素 促甲状腺激素 

分 类 号：R749.4[医药卫生—神经病学与精神病学]