微RNA在干细胞移植治疗心肌梗死中的作用  

MiRNA's Role in the Stem Cell Transplantation for Treatment of Myocardial Infarction

作　　者：王永涛[1] 马依彤[1] 

机构地区：[1]新疆医科大学第一附属医院心脏中心,乌鲁木齐830054

出　　处：《医学综述》2015年第14期2505-2507,共3页Medical Recapitulate

基　　金：新疆维吾尔自治区科技支撑计划项目(201233138)

摘　　要：微RNA(miRNA)是一类广泛存在于人体内的含约22个核苷酸的非编码小分子单链RNA,通过与靶信使RNA 3'非翻译末端特异性结合,在转录后水平调节靶基因翻译。近年来,国内外研究发现,miRNA参与众多心血管疾病的病理生理过程,并可通过调控细胞分化、血管新生、细胞凋亡等过程影响干细胞移植治疗心肌梗死。该文综合当前文献,就miRNA在干细胞移植治疗心肌梗死中的作用予以综述。MicroRNA（ miRNA） is a non-coding small single stranded RNA of about 22 nucleotides, widely exist in the human body.It regulates the translation of target gene at the post transcriptional level through specific binding with the target mRNA 3′untranslated terminal.miRNA participates in the patho-physiology of many cardiovascular diseases,which can affect stem cell transplantation in the treatment of myo-cardial infarction by regulating cell differentiation , angiogenesis, apoptosis and other processes.Here is to make a review of MiRNA′s role in the stem cell transplantation for treatment of myocardial infarction .

关 键 词：心肌梗死 微RNA 干细胞 

分 类 号：R363[医药卫生—病理学]