发作性睡病研究进展  

Advance in Study of Narcolepsy

作　　者：郝茂林[1] 商笑[1] 杜怡峰[1] 

机构地区：[1]山东大学附属省立医院神经内科,济南250022

出　　处：《医学综述》2015年第14期2585-2588,共4页Medical Recapitulate

摘　　要：发作性睡病是一种慢性睡眠障碍性疾病。近年来经过不断研究,发作性睡病被认为是一种免疫介导性疾病,该病与HLA-DQB1*06:02基因和下丘脑分泌素密切相关,同时2个新的易患基因也已明确。诊断标准的制订更利于该病的早期诊断,一些新药的研制成功和给药方式的改进也提高了发作性睡病的疗效。在今后的工作中,通过对发作性睡病免疫机制的深入研究,将为临床治疗该病提供更好的实验依据。Narcolepsy is a chronic sleep disorder.In recent years,with continuous research,it is known as a kind of immune-mediated disease,related with HLA-DQB1 ＊06：02 gene and hypocretin,and two new susceptibility genes have also been clarified at the same time.Establishing related criteria is better for the early diagnosis of narcolepsy,and successful development of new drugs and improved administration have also improved the efficacy of the treatment.In the future,in-depth study of the immune mechanism of narcolepsy will provide better experimental basis for the clinical treatment .

关 键 词：发作性睡病 HLA-DQB1＊06:02基因 下丘脑分泌素 

分 类 号：R741[医药卫生—神经病学与精神病学]