nup88、Ataxin-3和PTEN在结直肠癌中表达关系的研究  

The Research of Nup88,Ataxin-3 and PTEN Expression Relations in Colorectal Cancer

作　　者：张建波 

机构地区：[1]平山县人民医院外2科,河北平山050400

出　　处：《医学综述》2015年第14期2674-2676,共3页Medical Recapitulate

摘　　要：目的检测核孔蛋白复合体蛋白88（nup88）、脊髓小脑共济失调症相关蛋白3（Ataxin-3）和第10号染色体缺失的磷酸酶和张力蛋白同源等位基因（PTEN）在结直肠癌中的表达特点,探讨三者的表达关系。方法选择2011年1∽12月平山县人民医院外2科103例结直肠癌术后患者作为观察组,选择68例正常结肠黏膜作为对照组,采用免疫组织化学检测两组nup88、Ataxin-3和PTEN的表达,分析其相关性。结果观察组中nup88表达的阳性率显著高于对照组[71.8%（74/103）比20.6%（14/68）],观察组中Ataxin-3和PTEN表达的阳性率显著低于对照组[35.0%（36/103）比82.4%（56/68）,19.4%（20/103）比73.5%（50/68）],差异有统计学意义（P〈0.05）。观察组中nup88、Ataxin-3和PTEN的表达在不同Dukes分期、有无淋巴结转移、是否有癌结节及脉管浸润间阳性率差异有统计学意义（P〈0.05）;线性相关分析显示,观察组中nup88、Ataxin-3与PTEN的表达无相关性（P〉0.05）。结论结直肠癌中nup88、Ataxin-3和PTEN异常表达,但是三者不具有协同作用,3种蛋白可能是通过各自的通路发挥促肿瘤进展的作用。Objective To detect the expression characteristics of nuclear pore complex protein 88 （nup88）, spinal cord ceredellar ataxia syndrome related proteins 3 （Ataxin-3） and phosphatase and tensin homolog deleted on chromosome ten （ PTEN） in colorectal cancer,focusing on the expression relationships between them.Methods A total of 103 postoperative patients with colorectal cancer were chosen in Pings-han county in Surgery Department Two of Pingshan County People′s Hospital from Jan.to Dec.2011 as obser-vation group,and another 68 cases of normal colonic mucosa were included as control group,and nup88, Ataxin-3 and PTEN expression of the two groups were detected using immunohistochemical method,and the correlation was analyzed.Results nup88 expression in observation group was significantly higher than that in control group[71.8%（74/103） vs 20.6%（14/68）],Ataxin-3 and PTEN expression rate in observation group were significantly lower than those in the control group [ 35.0%（ 36/103 ） vs 82.4%（ 56/68 ） ,19.4%（ 20/103） vs 73.5%（50/68）],the difference were statistically significant（P〈0.05）.The expression of nup88, Ataxin-3 and PTEN in observation group and Dukes staging,lymph node metastasis,whether to have carcinoma nodules and vascular invasion were closely related;linear correlation analysis showed nup88,Ataxin-3 in the observation group and the expression of PTEN had no relevance（P 〉0.05）.Conclusion The expression of nup88,Ataxin-3 and PTEN in colorectal cancer is abnormal,but no synergy of them is observed,so the three kinds of proteins may play the role of promoting tumor progression through their respective pathways .

关 键 词：结直肠癌 核孔蛋白复合体蛋白88 脊髓小脑共济失调症相关蛋白3 第10号染色体缺失的磷酸酶和张力蛋白同源等位基因 

分 类 号：R735[医药卫生—肿瘤]