米邦塔仙人掌果胶对慢性不可预知温和应激小鼠绝望症状的改善作用  

Study on the improvement of milpa alta cactus pectin on desperate symptoms in mice exposed to chronic unpredictable mild stress

作　　者：肖同楚 黄朝明 杨兴娥 湛进进[2] 郭莲军[2] 

机构地区：[1]湖北省宜昌市夷陵区妇幼保健院,湖北宜昌443100 [2]华中科技大学同济医学院,湖北武汉430030

出　　处：《现代中西医结合杂志》2015年第24期2630-2631,2675,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：中央高校基本科研业务费专项资金资助项目(2011TS073);国家重大创新平台重点资助新药研发项目(2009ZX09301-014)

摘　　要：目的研究米邦塔仙人掌果胶(MCP)对慢性不可预知温和应激(CUMS)小鼠绝望症状的改善作用。方法雄性昆明种小鼠随机分为空白对照组、模型组、MCP低剂量组(50 mg/kg)、MCP中剂量组(100 mg/kg)、MCP高剂量组(200 mg/kg)。除空白对照组不进行任何应激处理外,其余组均进行CUMS,各MCP组均在进行CUMS期间每天灌胃相应剂量MCP。造模结束24 h后进行悬尾实验,48 h后进行强迫游泳实验。结果模型组悬尾实验潜伏期显著短于空白对照组(P<0.01),累计不动时间显著长于空白对照组(P<0.01);MCP高剂量组潜伏期显著长于模型组(P<0.05),MCP中、高剂量组累计不动时间显著短于模型组(P均<0.01)。模型组强迫游泳实验潜伏期显著短于空白对照组(P<0.01),累计不动时间显著长于空白对照组(P<0.01);MCP各给药组潜伏期与空白对照组比较差异均无统计学意义(P均>0.05),而MCP高剂量组累计不动时间显著短于模型组(P<0.05)。结论 MCP能较好地缓解CMS小鼠的行为绝望症状。Objective It is to investigate the effect of milpa aha cactus pectin （MCP） on desperate symptoms in mice ex- posed to chronic unpredictable mild stress （CUMS）. Methods The male Kunming mice were randomly divided into 5 groups such as control group, CUMS ＋ Vehicle group, CUMS ＋ MCP 50 mg/kg group, CUMS ＋ MCP 100 mg/kg group, and CUMS ＋ MCP 200 mg/kg group. Except the control group, the other groups were exposed to CUMS for 6 weeks. And during this peri- od, the animals were treated with~ corresponding drug by intragastric administration. While the ends of the model, the tail sus- pension test （TST） was carried out after 24 hours, and the forced swimming test （FST） were conducted after 48 hours. Re- sults In TST, the latency of the CUMS ＋ Vehicle group was significantly shorter （P 〈 0.01 ） , and the immobility time was sig- nificantly longer than that of the control group （ P 〈 0.01 ） ; the latency of the CUMS ＋ MCP 200 mg/kg group was significantly longer than that of the CUMS ＋ Vehicle group （P 〈 0.05 ） , and the immobility time of the CUMS ＋ MCP 200 mg/kg and 100 mg/kg groups was significantly shorter than that of the COMS ＋ Vehicle group （ all P 〈 0.01 ）. In FST, the latency of the CUMS ＋ Vehicle was significantly shorter （P 〈 0.01 ） , and the immobility time was significantly longer than that of control group （P 〈 0. 01 ） ; the latency of the MCP groups was no significant difference compared with the control group （all P 〉 0. 05 ） , and the immobility time of the CUMS ＋ MCP 200 mg/kg groups was significantly short than that of the CUMS ＋ Vehicle group （P 〈 0. 05 ）. Conclusion MCP can improve the desperate symptoms in mice exposed to CUMS.

关 键 词：米邦塔仙人掌果胶 慢性不可预知温和应激 绝望症状 小鼠 

分 类 号：R-332[医药卫生]