早期与延期介入栓塞治疗颅内复杂动脉瘤的比较研究  

Comparative study of early and delayed interventional embolization therapy in treating complex intracranial aneurysms

作　　者：王玉春[1] 

机构地区：[1]黑龙江省大庆市大庆油田总医院,163001

出　　处：《检验医学与临床》2015年第15期2212-2213,共2页Laboratory Medicine and Clinic

摘　　要：目的比较早期与延期介入栓塞治疗颅内复杂动脉瘤的临床效果。方法选取2010年8月至2012年6月大庆油田总医院收治的颅内复杂动脉瘤患者84例作为研究对象,随机分为早期介入栓塞治疗的观察组和延期介入栓塞治疗的对照组,每组各42例,比较2组患者术后神经功能和精神状态。结果观察组的精神状态通过简易精神状态量表(MMSE)、神经营养因子(NTF)、神经生长因子(NGF)以及脑源性神经营养因子(BDNF)水平均明显高于对照组,且与手术时机呈负相关;中国脑卒中临床神经功能缺损程度评分(CSS)明显低于对照组,且与手术时机呈正相关(P<0.05)。结论早期进行介入栓塞治疗有助于改善术后的神经功能,具有积极的临床价值。Objective To study the effect of early and delayed interventional embolization therapy in treating complex intracranial aneurysms .Methods 84 patients with complex intracranial aneurysm in our hospital from Au‐gust 2010 to June 2012 were selected as the research subjects and randomly divided into the observation group（n=42） treated by the early intervention embolization and the control group（n= 42） treated by the delayed interventional embolization .Then postoperative neurologic function and mental state were compared between the two groups .Re‐sults The mini‐mental state examination（MMSE） score ,levels of nerve growth factor（NGF） and brain derived neu‐rotrophic factor（BDNF） in the observation group were significantly higher than those in the control group and were negatively correlated with operation opportunity ;While the CSS score in the observation group was significantly low‐er than that in control group and was positively correlated with the operation opportunity （P 〈 0 .05） .Conclusion Early conducting the interventional embolization therapy is conducive to improve the postoperative nerve function and has the active clinical value .

关 键 词：颅内动脉瘤 介入治疗 栓塞治疗 神经功能 

分 类 号：R739.410.5[医药卫生—肿瘤]