谷胱甘肽-S-转移酶P1基因多态性与炎症性肠病易感性的Meta分析  

Study on relationship between glutathione S-transferase P1 genetic polymorphisms and susceptibility to inflammatory bowel disease: a Meta-analysis

作　　者：王曼[1] 高峰[1] 

机构地区：[1]新疆维吾尔自治区人民医院消化科,乌鲁木齐830000

出　　处：《中华临床医师杂志（电子版）》2015年第14期102-106,共5页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的研究谷胱甘肽．S-转移酶P1（GSTPl）基因多态性与炎症性肠病（IBD）发病的关系。方法全面检索和筛选相关文献，通过Meta分析的方法对纳入研究结果进行数据合并，计算比值比（OR值）及95％的可信区间（95％CI），并评价其发表偏倚，运用敏感性分析评价结果的可靠性。结果实际纳入文献6篇，共包括1219例溃疡性结肠炎（uc）患者，538例克罗恩病（CD）患者和正常对照组2403例，进行Meta分析和关联性研究；GSTPl基因多态性与UC显性基因模型、隐性基因模型及等位基因的尸值、合并OR值及95％c玢别如下：（GG＋GA）VS．AA：P=0．05，OR=1．76，95％C，1．00～3．08；GGvs．（GA＋AA）：P=0．03，O贝=1．52，95％C71．05～2．2l：Gvs．A：P=0．03，OR=I．59，95％C11．04～2．45。我们根据种族的不同进行亚组分析，中国汉族人群显性基因模型、隐性基因模型及等位基因的P值、合并OR值及95％C玢别如下：（GG＋GA）vs．AA：P〈0．00001，OR=2．20，95％C11．79～2．71；GGw．（GA＋AA）：P〈0．00001，OR=I．82，95％C11．51～2．20：G＂MS．A：P〈0．00001，OR=I．89，95％CI1．66～2．17。我们共检索NIJ2篇欧洲人群GSTPl基因多态性与CD关系的研究，其显性基因模型、隐性基因模型及等位基因的P值、合并OR值及95％a分别如下：（GG＋GA）w．AA：P=0．92，DR=1．03，95％C10．59～1．81；GG坩．（GA＋AA）：P=0．53，OR=1．40，95％C10．49～4．00；Gvs．A：P=0．75，OR=1．09，95％C10．66～1．79。结论GSTPl基因多态性可能是中国汉族人群UC的危险因素，其与中国汉族人群UC关系尚缺乏相关研究，GSTPl基因多态性与欧洲人群UC和CD的发病风险可能无明显关联。Objective To evaluate the effect of glutathione S-transferase P1 （GSTP1） gene polymorphism on inflammatory bowel disease （IBD） susceptibility. Methods We included all the published studies on the association between GSTP 1 gene polymorphism and IBD. A Meta-analysis was employed to summarize all these studies, calculate P values, the pooled odds ratio （OR） and its 95% confidence interval （95% CO, and test the overall effects. The Egger＇s publication bias analysis and sensitivity analysis were carried out to evaluate the reliability and stability of the Meta-analysis. Results A total of 6 literatures were retrieved. We genotyped 1 219 patients with ulcerative colitis （UC）, 538 patients with Crohu disease （CD） and 2 403 healthy controls for the Meta-analysis. GSTP1 gene polymorphism and UC dominant gene model, recessive gene model and alleles, their P values, the pooled OR and 95% CI were respectively as follows, （GG＋GA） vs. AA, P=0.05, OR=1.76, 95% CI 1.00-3.08; GG vs. （GA＋AA）, P=0.03, OR=1.52, 95% CI 1.05-2.21; G vs. A, P=0.03, OR=1.59, 95% CI： 1.04-2.45. The subgroup analysis by ethics revealed that the P values, the pooled OR and 95% CI of dominant gene model, recessive gene model and alleles in Chinese Han population were respectively as follows, （GG＋GA） vs. AA, P〈0.000 01, OR=2.20, 95% C1 1.79-2.71; GG vs. （GA＋AA）, P〈0.000 01, OR=1.82, 95% CI 1.51-2.20; G vs. A, P〈0.000 01, OR=1.89, 95% C1 1.66-2.17. Study the relationship between GSTP1 gene polymorphism and CD, we had retrieved two articles about the European people, its P values, the pooled OR and 95% Clwere respectively as follows, （GG＋GA） vs. AA, P=0.92, OR=l.03, 95% CI0.59-1.81; GG vs. （GA＋AA）, P=0.53, OR=l.40, 95% CI 0.49-4.00; G vs. A, P=0.75, OR=l.09, 95% CI 0.66-1.79. Conclusion GSTP 1 gene polymorphism may be a risk factor of UC in Chinese Han population, but their relationship is still lack of relevant research. GSTP 1 gene polymorphism may be not obviously correlated with the devel

关 键 词：谷胱甘肽转移酶 多态性 单核苷酸 结肠炎 溃疡性 CROHN病 META分析 炎症性肠病 

分 类 号：R574[医药卫生—消化系统]