超声造影在腹腔镜射频消融治疗原发性肝癌中的效果  

Effect of contrast-enhanced ultrasonography in laparoscopic radiofrequency ablation in treatment of primary liver cancer

作　　者：白文庆[1] 苏新娟[1] 胡杰[1] 

机构地区：[1]郑州大学附属洛阳中心医院超声科,洛阳471002

出　　处：《中国当代医药》2015年第22期102-104,共3页China Modern Medicine

基　　金：河南省洛阳市科技发展计划项目(1401085A-4)

摘　　要：目的观察超声造影（CEUS）在腹腔镜射频消融（LURFA）治疗原发性肝癌中的临床效果。方法选取2012年1月~2014年10月在我院接受原发性肝癌治疗的患者45例,按随机数字表法分为观察组（D组,超声造影＋腹腔镜射频消融）25例,对照组（C组,腹腔镜射频消融）20例。比较两组患者术后消融率及术后并发症（发热、出血、疼痛等）的发生情况,术后1个月通过CEUS对手术疗效进行评价。随访术后6个月患者肿瘤无进展生存率及复发情况。结果 D组术中射频消融的肿瘤直径为（2.92±0.89）cm,较术前超声直径[（2.21±0.32）cm]增大（P〈0.05）,C组射频消融肿瘤直径与术前比较,差异无统计学意义（P〉0.05）;术后1个月复查增强CT扫描,D组术前肿瘤76个,原位灭活或稳定68个（消融率89.4%）,C组术前肿瘤59个,原位灭活或稳定40个（消融率67.8%）,C组消融率较D组升高（P〈0.05）;术后6个月复查CT,D组肿瘤无进展生存率为78.9%,C组为59.3%,D组高于C组（P〈0.05）。术后两组均有发热、出血、疼痛等并发症,无肝衰竭等并发症,并发症发生率比较差异无统计学意义（P〉0.05）。结论超声造影在腹腔镜射频消融治疗原发性肝癌中,能够提高肿瘤消融率及术后6个月的肿瘤无进展生存率,且不增加术后并发症,值得临床推广。Objective To observe the clinical effect of contrast-enhanced ultrasonography （CEUS） in laparoscopic ra-diofrequency ablation （LURFA） in treatment of primary liver cancer. Methods 45 patients with primary liver cancer re-ceived therapy from January 2012 to October 2014 of our hospital.Patients were randomly divided into observation group （D group,CEUS and LURFA） （n=25） and control group （C group,LURFA） （n=20） according to random number table.Ablation rateand complications such as fever,bleeding and pain of postoperation were compared between two groups.CEUS was reviewed for efficacy evaluation after 1 month of operation.Progression free survivalcondition of pa-tients was followed-up. Results Tumor diameter of ablation in D group was （2.92±0.89） cm,which was significantly big-ger than that of （2.21±0.32） cm before operation （P〈0.05）.Tumor diameter of ablation in C group had no significant dif-ference compared with preoperation （P〉0.05）.Enhanced CT scans reviewed after 1 month of operation,there was 76 tu-mors in D group before operation,68 in situ inactivated or stability （ablation rate was 89.4%）.59 tumors in C group be-fore operation,40 in situ inactivated or stability （ablation rate was 67.8%）,and the ablation rate was higher in D group （P〈0.05）.6 months after operation,progression free survival rate in D group was 78.9%,which was significantly higher than that of 59.3% in C group （P〈0.05）.Complications such as fever,bleeding and pain were all appeared between two groups.There was no complication such as liver failure between two groups,and the incidence rate had no statistical dif-ference （P〉0.05）. Conclusion CEUS in LURFA in treatment of primary liver cancer can improve ablation rate of tumor, progression free survival rate after 6 months of operation and not increase complications.It is worth popularizing in clin-ical.

关 键 词：超声造影 腹腔镜 射频消融 原发性肝癌 

分 类 号：R735.7[医药卫生—肿瘤]