盐酸法舒地尔治疗蛛网膜下隙出血后并发迟发脑血管痉挛的效果观察  

Effect observation of fasudil hydrochloride in the treatment of delayed cerebral vasospasm after subarachnoid hemorrhage

作　　者：张会[1] 赵卫东[1] 靳红林[1] 

机构地区：[1]河南省新乡市第一人民医院神经内科,河南新乡453000

出　　处：《中国当代医药》2015年第22期136-138,144,共4页China Modern Medicine

摘　　要：目的探讨盐酸法舒地尔治疗蛛网膜下隙出血（SAH）后并发迟发脑血管痉挛的临床效果。方法选取2010年6月~2012年5月在本院神经内科住院的52例SAH患者作为研究对象,按照住院就诊先后顺序随机分成对照组（27例）和治疗组（25例）。两组均进行常规治疗,治疗组加用法舒地尔治疗,对照组加用尼莫地平治疗,疗程均为2周。观察两组的总有效率及脑血管痉挛情况。结果治疗组的总有效率为88.0%,明显高于对照组的70.4%（P〈0.05）;治疗后,两组的脑血管痉挛指数均较治疗前显著降低（P〈0.05）,且治疗组脑血管痉挛指数低于对照组（P〈0.05）。结论盐酸法舒地尔治疗SAH后并发迟发脑血管痉挛的效果显著,是一种较尼莫地平同样安全但疗效更好的药物。Objective To explore the clinical effect of fasudil hydrochloride in the treatment of delayed cerebral va-sospasm after subarachnoid hemorrhage （SAH）. Methods 52 patients with SAH from June 2010 to May 2012 in depart-ment of neurology of our hospital were selected as research object,and they were randomly divided into the control group （27 cases） and treatment group （25 cases） according to the order of visiting the hospital.The treatment group was treated with fasudil hydrochloride,the control group was treated with nimodipine on the basis of the conventional thera-py respectively.The treatment course was 2 weeks.The total effective rate and the condition of cerebral vasospasm in two groups was observed. Results The total effective rate of the treatment group was 88.0%,which was significantly higher than 70.4% of the control group （P〈0.05）.After treatment,The index number of cerebral vasospasm in two groups was significantly lower than that before treatment （P〈0.05）,and the index number of cerebral vasospasm in treatment group was lower than that of control group （P〈0.05）. Conclusion The effect of asudil hydrochloride in the treatment of delayed cerebral vasospasm after SAH is significant,and which is a relatively safe drug and even much better in cura-tive effect compared with nimodipine.

关 键 词：蛛网膜下隙出血 脑血管痉挛 盐酸法舒地尔 尼莫地平 

分 类 号：R743.35[医药卫生—神经病学与精神病学]