超声造影时间-强度曲线诊断前列腺癌  

Time-intensity curve of contrast-enhanced transrectal ultrasonography in diagnosis of prostate cancer

作　　者：陆殿元[1] 沈理[2] 蔡建荣[2] 陈玉华[2] 陈亚青[1] 

机构地区：[1]上海交通大学医学院附属新华医院超声科,上海200092 [2]上海交通大学医学院附属新华医院崇明分院超声科,上海202150

出　　处：《中国医学影像技术》2015年第8期1255-1258,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金面上项目(81271595);上海市科学技术委员会科研计划项目(14140901802;10JC1411400;10411952000;09411963800)

摘　　要：目的探讨CEUS时间-强度曲线诊断前列腺癌的价值。方法对117例可疑前列腺癌患者行经直肠CEUS检查,以穿刺病理证实前列腺癌和非前列腺癌病灶的部位作为定量分析的ROI,得到各部位的时间-强度曲线及达峰时间、增强强度、曲线下面积定量参数,分析病灶CEUS定量参数的差异。结果前列腺癌86例(86/117,73.50%)、非前列腺癌31例(31/117,26.50%)。前列腺癌病灶的达峰时间早于非前列腺癌病灶,增强强度和曲线下面积均高于非前列腺癌病灶(P均<0.05);前列腺癌周缘区达峰时间早于非前列腺癌病灶周缘区,增强强度和曲线下面积高于非前列腺癌病灶周缘区(P均<0.01)。结论 CEUS时间-强度曲线有助于前列腺癌尤其是周缘区前列腺癌的鉴别诊断,可提高前列腺癌穿刺活检的阳性率。Objective To investigate the clinical value of time-intensity curve of contrast-enhanced transrectal ultrasonog- raphy （CETRUS） in diagnosis of prostate cancer. Methods Totally 117 patients suspected of prostate cancer underwent CETRUS. Biopsy-proved prostate cancer lesions and non-prostate cancer lesions were selected as ROI, and time-intensity curve were reconstructed. The hemodynamic parameters including time-to-peak （TTP）, peak intensity （PI） and area under the curve （AUC） were obtained. The differences of the hemodynamie parameters between prostate cancer and non-prostate cancer were analyzed. Results In all 117 patients, 86 （86/117, 73.50%） was prostate cancer and 31 （31/117, 26.50%） were non-prostate cancer. Compared with non-prostate cancer lesions, prostate cancer lesions had lower TTP, higher PI and AUC （all P〈0.05）. After dividing the lesions into peripheral zone （PZ） and transitional zone （TZ）, statistical analy- sis revealed that the PZ prostate cancer lesions had lower TTP, higher PI and AUC than the non-prostate cancer lesions lo- cated in PZ （all P 〈0.01）. Conclusion The quantitative analysis of CETRUS is helpful in the differential diagnosis of prostate cancer, especially the PZ prostate cancer, which can increase the positive rate of prostate biopsy.

关 键 词：超声检查 前列腺肿瘤 造影剂 时间-强度曲线 定量分析 

分 类 号：R737.25[医药卫生—肿瘤] R445.1[医药卫生—临床医学]