肝细胞生长因子及其受体c-Met表达与胃癌肝转移的相关性  

The relationships of HGF and c-Met expression with liver metastasis of gastric cancer

作　　者：孙燕来[1] 李增军[1] 

机构地区：[1]山东省肿瘤医院外四病区,济南市250117

出　　处：《实用医学杂志》2015年第16期2634-2637,共4页The Journal of Practical Medicine

基　　金：山东省科技发展计划项目(编号:2013GSF11834);山东省医学科学院科技计划项目(编号:2014-04);济南市科技计划高校自主创新项目(编号:201401253)

摘　　要：目的:探讨肝细胞生长因子及其受体c-Met的表达及临床病理因素与胃癌肝转移的关系。方法:应用免疫组化方法检测HGF和及其受体c-Met在胃癌和肝转移癌组织中的表达情况,通过对比两者在原发癌和肝转移癌组织中的不同表达状态,探讨二者及临床病理因素与胃癌肝转移发生的关系。结果:实验组与对照组胃癌组织中HGF呈阳性表达率分别为68%和60%,两组比较差异具有统计学意义。实验组与对照组胃癌组织中c-Met呈阳性表达率分别为86%和68%,两组比较差异具有统计学意义。胃癌患者的淋巴结转移、HGF表达、c-Met表达与胃癌肝转移有关;而浸润深度、分化程度与胃癌肝转移无关。原发癌和肝转移癌HGF表达一致性分析存在显著差异。原发癌和肝转移癌c-Met表达一致性分析无显著差异。结论:HGF和c-Met的高表达与胃癌肝转移机制有关,对于c-Met表达程度的评估可能成为预测胃癌肝转移有价值的预后指标。Objective To investigate the relationships of HGF, c-Met expression and clinicopathological factors with liver metastasis of gastric cancer. Methods The tissues of primary tumors and corresponding liver metastasis were collected to detect the expression of HGF and c-Met by immunohistochemistry. Results The positive rates of HGF in the experimental group and the control group were 68% and 60%, respectively, with significant differences between two groups. The positive rates of c-Met of the two groups were 86% and 68%, respectively, with a significant difference between two groups. Lymph node metastasis, high expression of HGF and c-Met were significantly associated with liver metastasis of gastric cancer. The depth of invasion of bowel wall and degree of differentiation were not associated with the liver metastasis of gastric cancer. Conclusion High expressions of HGF and c-Met are closely associated with the liver metastasis mechanism of gastric cancer. The c-Met might be a useful indicator of liver metastasis in patients with gastric cancer.

关 键 词：胃肿瘤 肝细胞生长因子 C-MET 肝转移 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]