中性粒细胞与淋巴细胞比值在宫颈癌根治术预后评估中的价值  

Value of neutrophit-to-lymphocyte ratio in evaluation of prognosis in patients with early cervical cancer before radical resection

作　　者：杨军文[1] 吴玲玲[2] 倪观太[1] 

机构地区：[1]皖南医学院弋矶山医院妇产科,安徽省芜湖市241001 [2]中山大学附属第三医院妇产科,广州市510630

出　　处：《实用医学杂志》2015年第16期2662-2665,共4页The Journal of Practical Medicine

摘　　要：目的:探讨术前中性粒细胞与淋巴细胞比值(NLR)在宫颈癌根治术患者预后评估中的价值。方法:回顾性分析2007-2009年我院76例行宫颈癌根治术患者的临床资料,术前均未接受放化疗。以中位数NLR=1.94作为临界值,分为低NLR(NLR<1.94)和高NLR(NLR≥1.94)两组,对两组临床病理特征进行比较,单因素及Cox多因素评估NLR对宫颈癌预后的影响。结果:两组患者在深肌层浸润、淋巴结转移、病理分级及临床分期的差异有统计学意义(P<0.05)。单因素分析结果:NLR、临床分期、淋巴结转移及术后辅助治疗是患者预后的影响因素(P<0.05)。Cox多因素分析结果:NLR、临床分期和淋巴结转移是影响患者无瘤生存期独立因素(P<0.05),临床分期和淋巴结转移是影响患者总生存期的独立因素(P<0.05)。结论:术前高NLR可作为宫颈癌根治术后复发的独立因素,但并不是其预后独立因素。Objective To investigate the value of neutrophil-to-lymphocyte ratio in evaluation of prognosis in patients with early cervical cancer before radical resection. Methods A restropective study was performed in 76 patients who underwent radical resection for early cervical cancer in our hospital between 2007 and 2009. All patients were diagnosed by pathology. All patients did not accept neoadjuvant therapy, the median value of neutrophit-to-lymphocyte ratio （NLR） was 1.94 （0.73-9.31 in range）. Based on this value of 1.94 as threshold, all patients were divided into 2 groups： a low NLR（ ≤1.94, n = 38） group and a high NLR （ 〉 1.94, n = 38） group. Univariate and multivariate analyses were performed to assess the effectiveness of preoperative NLR to the prognosis in patients who underwent radical hysterectomy combined with pelvic lymph node dissection. Results The preoperative NLR was different significantly in the depth of stromal infiltration, lymphatic metastas, FIGO stage and pathological type between the low NLR group and the high NLR group. The high NLR group, lymphatic metastas, postoperative radiotherapy and FIGO stage Ⅱ were all risk factors for prognosis and disease-free survival in univariate analysis.Multivariate analysis revealed that NLR, lymphatic metastas and FIGO stage II were independent risk factors for disease-free survival. FIGO stage Ⅱ and lymphatic metastasis were independent risk factors for overall survival Conclusion Preoperative NLR was found to correlate to unfavorable histopathologic features of cervical cancer, The preoperative NLR may be used as a useful and easy biomarker for disease-free survival in patients with cervical cancer, but not an independent risk factor for poor prognosis.

关 键 词：宫颈肿瘤 中性粒细胞与淋巴细胞比值 预后 

分 类 号：R737.33[医药卫生—肿瘤]