乳腺血氧功能成像技术对乳腺癌新辅助化疗疗效评价研究  

Blood-oxygen functional imaging technique for evaluating efficacy of neoadjuvant chemotherapy in breast cancer patients

作　　者：苏洁之[1] 范平明[1] 郑立平[1] 吕鹏飞[1] 

机构地区：[1]海南医学院附属医院乳腺胸部肿瘤外科,海南海口570102

出　　处：《实用肿瘤杂志》2015年第4期346-348,共3页Journal of Practical Oncology

摘　　要：目的探讨乳腺癌患者在新辅助化疗中应用乳腺血氧功能成像技术的疗效评价和临床应用价值。方法35例乳腺癌患者分别在确诊前和4个疗程新辅助化疗结束后这2个阶段,对研究样本采用乳腺血氧功能检测来评价临床疗效,同时采用触诊法测量肿瘤大小,并根据实体肿瘤评价标准进行临床疗效评价,根据两组结果比较分析两种评价方法。结果接受新辅助化疗的35例乳腺癌患者中,32例血氧功能评价为显著,其中29例触诊法评价为显效(90.6%);3例血氧功能评价不显著,其中2例临床触诊法疗效评价为不显效(66.7%)。治疗前、后的血值和氧值变化差异有统计学意义(均P<0.05)。临床触诊疗效评价法和血氧功能疗效评价法间具有一致性与关联性(均P<0.05)。结论乳腺血氧功能成像技术与临床触诊法具有一致性和关联性,对乳腺癌新辅助化疗疗效评价有显著优势,应作为对现行临床触诊疗效评价方法的补充和提升。Objective To assess the application of blood-oxygen functional imaging techniques in the efficacy evaluation of neoadjuvant chemotherapy in breast cancer patients. Methods Thirty-five patients with breast cancer received neoadjuvant chemotherapy. Blood-oxygen function tests were performed before confirmed diagnosis and after 4 courses of chemotherapy. The results were compared with clinical efficacy as evaluated by palpation method. Results In 35 patients, 32 cases were evaluated by blood-oxygen function tests as marked response, of which 29 cases were evaluated as marked response by palpation （ 90.6% ） ; 3 cases were evaluated by blood-oxygen function test as unmarked response, of which 2 cases were evaluated as ineffective by palpation （66.7%）. Oxygen and blood values shown by blood-oxygen function tests before and after chemotherapy were significantly different （ both P 〈 0.05 ）. The results of palpation and blood-oxygen function tests were correlated and consistent （ both P 〈 0.05 ）. Conclusion Blood-oxygen functional imaging techniques and clinical palpation are consistent and complementary in evaluating the efficacy of neoadjuvant chemotherapy in breast cancer patients.

关 键 词：乳腺肿瘤 氧/血液 血氧测定法 化学疗法 辅助 乳腺肿瘤/药物疗法 治疗结果 

分 类 号：R737.9[医药卫生—肿瘤]