影响非小细胞肺癌肺叶袖状切除术后患者生存的预后因素分析  

Factors related to survival after bronchial sleeve resection in patients with non-small-cell lung cancer

作　　者：赵建强[1] 侯予龙[1] 臧豹[1] 唐德荣[1] 

机构地区：[1]南京医科大学附属淮安第一医院胸心外科,江苏淮安223300

出　　处：《实用肿瘤杂志》2015年第4期352-355,共4页Journal of Practical Oncology

摘　　要：目的分析非小细胞肺癌肺叶袖状切除术后影响患者长期生存的预后因素。方法回顾性研究收集行肺癌袖状切除术的非小细胞肺癌患者189例。采用Kaplan-Meier方法分析生存情况,Cox回归风险比例模型分析影响生存的预后因素。结果术后5年和10年生存率分别为43.6%和28.7%,中位生存时间56月。淋巴结N0和N1期患者5、10年生存率分别为64.3%、49.4%和46.6%、23.1%,而淋巴结转移N2期患者(39例)术后5年内均死亡;TNM分期,Ⅰ期、Ⅱ期5、10年生存率分别为57.5%、39.1%和51.2%、41.3%,而69例Ⅲ期患者均未生存至5年。结论支气管癌细胞残留、TNM分期Ⅲ期和淋巴结转移N2期是影响预后的独立因素。肺叶袖状切除术治疗局部非小细胞肺癌可切除局部肿瘤,同时又降低死亡率。Objective To investigate factors related to long-term survival after bronchial sleeve resection in patients with non-small-cell lung cancer （ NSCLC ）. Methods Clinical data of 189 patients with NSCLC undergoing bronchial sleeve resection were retrospectively analyzed. Overall survival was estimated according to Kaplan-Meier method. Multivariate analysis with prognosis variables was performed according to Cox proportional hazard regression model. Results The 5-year and 10-year survival rates were 43.6% and 28.7% , respectively; the median survival time was 56 months. The 5-year and 10-year survival rates were 64.3% ,49.4% and 46.6% , 23. 1% in patients with nodal status No and Nl respectively, and 57.7% , 39.1% and 51.2% , 41.3% in TNM stage Ⅰ and Ⅱ patients respectively. No patients with nodal status N2 or TNM stage m survived 5 years. Conclusion Bronchial sleeve resection improves survival for patients with NSCLC. Nodal status N2, TNM stage Ⅲand incomplete resection significantly impact the prognosis.

关 键 词：癌 非小细胞肺/外科学 肺切除术/方法 肺肿瘤/外科学 治疗结果 存活率分析 预后 回顾性研究 

分 类 号：R734.2[医药卫生—肿瘤] R730.56[医药卫生—临床医学]