纳米碳混悬注射液用于乳腺癌前哨淋巴结活检的临床研究  

Sentinel lymph node biopsy in breast cancer patients by using nanometer carbon suspension liquid

作　　者：管海涛[1] 马小斌[1] 刁岩[1] 单昌友 赵阳[1] 闵卫利[1] 刘小旭[1] 王西京[1] 

机构地区：[1]西安交通大学第二附属医院肿瘤病院,陕西西安710004

出　　处：《川北医学院学报》2015年第4期439-441,446,共4页Journal of North Sichuan Medical College

基　　金：西安交通大学第二附属医院2013年新技术;新疗法准入资助项目

摘　　要：目的：探讨纳米碳混悬注射液用于乳腺癌前哨淋巴结示踪活检的临床应用。方法：自2012年9月至2014年11月,选择我院收治的经病理检查确诊为乳腺癌的患者89例,于术前30~60 min将纳米碳混悬注射液1 mL分多点注入肿块、活检腔或乳晕区周围皮下。先行前哨淋巴结活检（ sentinel lymph node biopsy,SLNB）,再行腋窝淋巴结清扫。将前哨淋巴结及腋窝淋巴结送病理检查。结果：89例患者中87例检出SLN,检出率为97.75%（87/89）；共检出前哨淋巴结386个,平均每例为4.44个；准确率为97.70%（85/87）；灵敏度为93.94%（31/33）；假阴性率为6.06%（2/33）。结论：采用纳米碳混悬注射液作为淋巴结示踪剂用于乳腺癌前哨淋巴结活检具有简便、易行、可靠的优点,可用于临床实践。Objective：To investigate the effect of nanometer carbon suspension liquid on sentinel lymph nodes biopsy（ SLNB） in breast cancer. Methods：From September 2012 to November 2014,89 female cases of breast cancer（cT1-2N0M0）were selected. One milliliter nanometer carbon suspension liquid was subcutaneously injected around the mass,areola of breast or biopsy cavity at 4 ~6 points. And sentinel lymph nodes biopsy for pathological examination was done after 30-60 min. Then axillary lymph nodes radical dis-section was performed. Results：SLN was detected in 87of 89 cases,and detection rate is 97. 75%（87/89）. The sensitivity,accuracy, falsenegativeratewere97.70%（85/87）,93.94%（31/33）and6.06%（2/33）respectively.Conclusion：Nanometercarbonsuspen-sion liquid used in breast cancer sentinel lymph nodes biopsy is a method with good application prospect in clinical.

关 键 词：纳米碳混悬注射液 前哨淋巴结 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]