聚L-组氨酸/乙炔黑修饰电极上对乙酰氨基酚的电化学行为及测定  

Electrocatalytic behavior and determination of paracetamol on poly L-histidine/acetylene black modified electrodes

作　　者：李桂芳[1] 贾晶[1] 何晓英[1] 

机构地区：[1]西华师范大学化学化工学院,南充637002

出　　处：《分析试验室》2015年第8期902-906,共5页Chinese Journal of Analysis Laboratory

基　　金：四川省高校科技创新团队建设项目(2010008)资助

摘　　要：制备了聚L-组氨酸/乙炔黑修饰电极（Poly-（L-His）/AB/GCE）,并用交流阻抗法（EIS）对其进行了表征。用循环伏安法（CV）研究了对乙酰氨基酚（PCT）在该修饰电极上的电化学行为。在p H 6.5的B-R溶液中,PCT在该修饰电极上出现一对氧化还原峰,在40~320 m V/s扫速范围内,氧化峰电流（Ipa）及还原峰电流（Ipc）均与扫速V呈线性关系,表明该电极过程受吸附控制。用差分脉冲伏安法（DPV）测定不同浓度的PCT溶液,在8.0×10-7~1.0×10-4mol/L浓度范围内,氧化峰电流Ipa与PCT浓度呈线性关系,检出限（S/N=3）为7.72×10-8mol/L。运用该方法对样品感冒灵颗粒进行了检测,回收率为97.8%~105.2%。A poly L-aistidine/acetylene black modified electrode（ Poly-（ L-His）/AB/GCE） was prepared and characterized by electrochemical impedance spectroscopy（ EIS）. The electrochemical behavior of paracetamol（ PCT） on Poly-（ L-His） /AB /GCE were investigated by cyclic voltammetry（ CV）. A redox peak pair of PCT was obtained on the modified electrode in p H 6. 5 B-R buffer solution,and the linear relationship between redox peak currents（ Ipa and Ipc） and scanning rate in the range of 40 ~ 320 m V/s indicated that the electrode process of PCT was controlled by absorption. Differential pulse voltammetry was herein adopted to determine the concentration of PCT,which demonstrated a good linear relationship with peak currents in the range of 0. 8 ~100 μmol/L,and the detection limit（ S/N = 3） was 7. 72 × 10- 8mol/L. The method was further applied in the determination of PCT in Ganmaoling granules samples,with the recovery between 97. 8% and 105. 2%.

关 键 词：乙炔黑 L-组氨酸 对乙酰氨基酚 差分脉冲伏安法 

分 类 号：TQ460.7[化学工程—制药化工]