不同程度肺挫伤中sTREM-1及TNF-ɑ表达的动态变化及临床意义  

Dynamic changes of sTREM-1 and TNF-α in different degrees of pulmonary contusion and its clinical significance

作　　者：陆志斌[1] 周存荣[1] 占根生 吴卫兵[2] 徐晓晗[2] 吴延虎[2] 

机构地区：[1]南京市浦口区中心医院胸心外科,江苏南京211800 [2]江苏省人民医院胸心外科,江苏南京210029

出　　处：《临床肺科杂志》2015年第9期1655-1657,共3页Journal of Clinical Pulmonary Medicine

基　　金：南京市科技局项目(No 201303034)

摘　　要：目的探讨不同程度肺挫伤中可溶性髓样细胞触发受体-1(sTREM-1)及肿瘤坏死因子-ɑ(TNF-ɑ)的动态表达变化及其临床意义。方法设立健康体检人群组(A组)为对照组。用定酶联免疫吸附试验(ELISA)法测定不同程度肺挫伤组中血清sTREM-1和TNF-ɑ含量在患者入院时及入院后1天、3天、7天的变化。结果肺挫伤时血清sTREM-1较A组明显升高(P<0.05);TNF-ɑ含量(除B组第七天)较A组明显升高(P<0.05);sTREM-1及TNF-α在肺挫伤早期均明显升高,肺挫伤伤情越严重则升高越明显,同时随着病情的好转而逐渐表达下降。结论 sTREM-1及TNF-α可推荐作为临床评估肺挫伤严重程度及预后的有效指标。Objective To study the dynamic changes of soluble triggering receptor expressed on myeloid cell-1 （sTREM-1） and tumor necrosis factor-α （TNF-α） in different degrees of pulmonary contusion and its clinical significance. Methods The healthy people were selected as the control group. The levels of sTREM-1 and TNF-α in different degrees of pulmonary contusion and its changes on admission and 1, 3 and 7 days after admission were de-tected by enzyme linked immunosorbent assay （ELISA） method. Results The serum sTREM-1 in pulmonary contu-sion increased obviously compared with the control group （P〈0. 05）. The serum TNF-α content of lung contusion （except the seventh day in the group B） was significantly higher in the study group than in the control group （P〈0. 05）. The sTREM-1 and TNF-α increased significantly in early pulmonary contusion, and with the severity of pul-monary contusion. With the improvement of the disease, the levels of sTREM-1 and TNF-α decreased gradually. Conclusion TNF-α and sTREM-1 can be recommended as the effective index in evaluating the severity and progno-sis of pulmonary contusion.

关 键 词：STREM-1 TNF-ɑ 肋骨骨折 肺挫伤 

分 类 号：R655.3[医药卫生—外科学]