参附注射液对心脏骤停后综合征的治疗作用  

Therapeutic effects of Shenfu injection on post-resuscitation syndrome

作　　者：杨立山[1] 吴嘉荔[1] 陈伟[1] 李文峰[1] 陈中伟[1] 曹瑞[1] 

机构地区：[1]宁夏医科大学总医院急诊科,银川750004

出　　处：《中华急诊医学杂志》2015年第8期897-901,共5页Chinese Journal of Emergency Medicine

基　　金：宁夏回族自治区卫生厅科研计划项目（2012027）

摘　　要：目的评价参附注射液在治疗心脏骤停后综合征患者中的临床效果，探讨其作用机制。方法收集80例心脏骤停后自主循环恢复患者的临床资料，随机（随机数字法）分为实验组和对照组，实验组在常规治疗基础上加用参附注射液，对照组仅在常规治疗基础上加用等量生理盐水。分别对两组患者在治疗前及治疗后第3、7、14、28天进行脑功能分级（CPC）、格拉斯哥昏迷评分（Glasgow）及序贯器官衰竭估计评分（SOFA），统计两组患者呼吸机使用天数、总花费及病死率，通过统计学分析，对比两组患者经过不同治疗方案后CPC、Glasgow评分、SOFA评分、呼吸机使用总天数及总花费的差异。结果80例患者中有3例患者病历资料不完整，从病例中剔除，最终实验组37例，对照组4JD例。实验组存活病例在治疗后第3、7、14、28天CPC评分较对照组低（P〈0．05）；Glasgow评分实验组分别在治疗后第14、28天时较对照组高（P〈0．05）。SOFA评分实验组在治疗后第3、7、14天较对照组低（P〈0．05）。两组患者在治疗后第3、7、14、28天呼吸机使用天数、住院总花费比较，差异无统计学意义（P〉0．05）。两组患者病死率在第3、7、14天差异无统计学意义（P〉0．05），在治疗后第28天，实验组病死率低于对照组，差异有统计学意义（P〈0．05）。结论参附注射液可改善心脏骤停后综合征患者预后。Objective To evaluate the therapeutic effects of Shenfu injection （a Chinese herbal preparation of Aconitum and Ginseng） for the treatment of patients with post-resuscitation syndrome （PCAS） and to investigate its mechanism as well. Methods The data of 80 patients with restoration of spontaneous circulation （ROSC） after cardiac arrest were collected, and the patients were randomly divided into the experimental group and the control group. The patients in experimental group received Shenfu injection in addition to conventional treatment, and the patients in control group just had the conventional treatment. The cerebral performance classification （CPC） scores, Glasgow Coma Scales cores and sequential organ failure assessment （SOFA） scores before treatment and on the 3rd, 7da, 14th and 28thdays after treatment in the patients of two groups were monitored and compared. The length of ventilation time, total expenses and mortality of the patients were calculated and compared between two groups. Results The data of 3 patients were excluded from those of total 80 patients, because the information of those patients was not complete. Finally, there were 37 eases in experimental group and 40 patients in control group. The CPC scores of survived eases in experimental group were lower than those in control group on the 3td, 7th, 14th and 28th days after treatment （P 〈 0. 05 ）. The Glasgow Coma Scale scores in experimental group were higher than those in control group on the 14th and 28th days after treatment （ P 〈 0. 05 ）. The SOFA scores in experimental group were lower than those in control group on the 3rd, 7th and 14th days after treatment （P 〈 0.05）. There were no significant differences in length of ventilation time and total expenses between two groups on the 3rd ,7th, 14th and 28th days after treatment （ P 〉 0.05 ）. The mortality of the experimental group was lower than that in control group at the 28th day after treatment （P 〈 0. 05 ）. Conclusions The Shenfu injecti

关 键 词：心肺复苏 心脏骤停后综合征 脑复苏 参附注射液 

分 类 号：R541.78[医药卫生—心血管疾病]