ADC 值动态监测进展期胃癌化疗疗效的可行性研究  

The feasibility research of ADC value in dynamic monitoring to chemotherapy response of advanced gastric carcinoma

作　　者：赵娓娓[1] 全志永[2] 陈燕[3] 王珂[1] 任芳[1] 赵青川[4] 文娣娣[1] 侯炜寰[1] 潘奇[1] 李娜[1] 任静[1] 宦怡[1] 

机构地区：[1]第四军医大学西京医院放射科,陕西西安710032 [2]第四军医大学西京医院核医学科,陕西西安710032 [3]香港大学深圳医院 [4]第四军医大学西京消化病医院

出　　处：《实用放射学杂志》2015年第8期1269-1272,1277,共5页Journal of Practical Radiology

基　　金：国家自然科学基金项目（81220108011,81370039）;西京医院临床高新技术新业务助推项目（XJGX13LC11）.

摘　　要：目的：探讨扩散加权成像（DWI）及表观扩散系数（ADC）在进展期胃癌化疗疗效动态监测中的应用价值。方法42例病理证实的进展期胃癌患者，分别于化疗前、化疗后3 d、7 d、30 d 和60 d 行 T2 WI-MRI、DWI-MRI 检查。测量化疗前和化疗后60 d 横轴位肿瘤最大径，以及化疗前及化疗后各时间点肿瘤 ADC 值，分析各疗效组化疗前和化疗后不同时间点 ADC 值差异。结果部分有效（PR）组化疗前、化疗后3 d、7 d、30 d、60 d ADC 值呈上升趋势，化疗前与化疗后各时间点的 ADC 值差异有统计学意义（P 〈0.05）；稳定（SD）组化疗前、化疗后3 d、7 d、30 d ADC 值变化呈上升趋势，于化疗后60 d ADC 值有所下降，化疗前与化疗后各时间点的 ADC 值差异有统计学意义（P 〈0.05）。结论 DWI 及 ADC 值可动态观察和早期定量监测进展期胃癌化疗疗效。Objective To evaluate the value of DWI and ADC value in monitoring the chemotherapy response of advanced gastric carcinoma dynamically.Methods 42 advanced gastric carcinoma patients who were confirmed by histopathology underwent T2 WI and DWI examinations at pre-chemotherapy,post-chemotherapy 3 d,7 d,30 d and 60 d respectively.The longest diameters of tumor pre-chemotherapy and post-chemotherapy 60 d were measured on axial T2 WI,meanwhile the ADC values at different time points were calculated.The mean ADC value among pre-and post-chemotherapy of each group （PR and SD）was compared.Results The ADC value of PR group increased gradually.The mean ADC value before therapy was statistically lower than those at differ-ent time points post-chemotherapy （P 〈 0.05）.The ADC value of SD group increased gradually from pre-chemotherapy to post-chemotherapy 30 d,and then the ADC value decreased at post-chemotherapy 60 d.The differences of the mean ADC values in differ-ent time points were statistically significant （P 〈 0.05）.Conclusion DWI and ADC value can dynamically,quantitatively and early detect and monitor the chemotherapy response of advanced gastric carcinoma.

关 键 词：胃癌 扩散加权成像 表观扩散系数 化疗疗效 

分 类 号：R735.2[医药卫生—肿瘤]