安宫牛黄丸加减治疗脑出血急性期脑损伤的临床疗效及对脑钠肽水平的影响  

The Clinical Effects of Modified Angong Niuhuang Pill Treatment on Cerebral Hemorrhage in the Acute Stage of Brain Injury and Level of Brain Natriuretic Peptide

作　　者：李志刚[1] 卓友光 张国明[1] 蒋瑾[1] 

机构地区：[1]广东省广州市第八人民医院,广东广州510440

出　　处：《中国中医急症》2015年第8期1448-1450,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：广东省中医药管理局科研课题(20132085)

摘　　要：目的观察安宫牛黄丸加减治疗脑出血急性期脑损伤患者的临床疗效及对其血浆脑钠肽(BNP)水平的影响。方法将80例患者按随机数字表法分为对照组和观察组各40例。并取40例健康体检者为正常对照组。对照组给予基础治疗,观察组在基础治疗基础上加用安宫牛黄丸加减口服或鼻饲治疗,连续14 d。比较两组临床疗效、GCS评分、GOS评分分级以及患者血浆中BNP水平。结果观察组总有效率92.50%高于对照组的80.00%(P<0.05)。治疗前对照组与观察组GCS评分差别不大(P>0.05),且均低于正常对照组(P<0.05)。治疗后两组GCS评分与治疗前比较均升高(P<0.05),但仍低于正常对照组(P<0.05);且治疗后观察组GCS评分优于对照组(P<0.05)。治疗后1个月,观察组和对照组预后情况比较良好,GOS评分均大于3分,但GOS评分均低于正常对照组(P<0.05)。且观察组GOS评分高于对照组(P<0.05)。治疗前对照组和观察组两组BNP水平差别不大(P>0.05)。治疗后,两组BNP水平与治疗前比较均升高(P<0.05),但低于正常对照组(P<0.05),且观察组BNP水平优于对照组(P<0.05)。结论安宫牛黄丸加减治疗脑出血急性期脑损伤临床疗效好,能降低患者GCS评分、GOS评分等级和BNP水平。Objective： To observe The clinical effects of Modified Angong Niuhuang Pill treatment on cerebral hemorrhage in the acute stage of brain injury and Level of Brain Natriuretic Peptide. Methods： 80 cases were randomly divided into the control group and the observation group with 40 cases in each group. The control group were given basic treatment,while the observation group received extra Modified Angongniuhuang Pill with the way of oral or nasal feeding. The treatment lasted for 14 days. The two groups were compared in clinical effects,GCS scores, GOS scores and the level of BNP. Results ： the total efficiency of the observation group 92.50% was higher than that of the control group 80.05%（P 〈 0.05）. Before treatment,there was few difference in GCS scores be- tween the two groups （P〉 0.05）, the observation group lower than the control group （P〈 0.05）. Compared with pre-treatment,the GCS scores were increased after treatment,the observation group still lower than the control group （P〉 0.05）,and the GCS score of the observation group was better than that of the control group. After 1 month＇s treatment, the prognosis of both groups were good. GOS scores were more than 3,but less than the control group （P〈 0.05）. besides,the GOS score was higher than that of the control group （P〈 0.05）. Before treatment, there was few difference in the level of BNP between the two groups （P〉 0.05）. In both groups,the levels of BNP were increased after treatment,the observation group still lower than the control group （P〈 0.05）, and the level of BNP of the observation group was better than that of the control group（P〈 0.05）. Conlusion： The modified treat- ment of Angong Niuhuang Wan on cerebral hemorrhage in the acute stage of brain injury has a good effect,and can reduce the GCS scores, the class of GOS scores and the level of Brain Natriuretic Peptide

关 键 词：脑出血 安宫牛黄丸加减 临床疗效 脑钠肽 

分 类 号：R743.34[医药卫生—神经病学与精神病学]