磁共振氧摄取分数成像在缺血性脑卒中的应用初探  

The preliminary application of oxygen extraction fraction imaging in ischemic stroke:a 3T MRI study

作　　者：郭林英[1] 张顺[1] 石晶晶[1] 张水霞[1] 姚义好[1] 朱文珍[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院放射科,武汉430030

出　　处：《放射学实践》2015年第8期817-821,共5页Radiologic Practice

基　　金：国家"十二五"科技支撑计划项目(2011BAI08B10);国家自然科学基金项目(81171308;81401389)

摘　　要：目的:初步探讨磁共振氧摄取分数(OEF)成像在缺血性脑卒中的应用价值。方法:本研究纳入13例缺血性脑卒中患者,均行常规MRI序列(T1WI、T2WI、T2-FLAIR)、DWI、三维动脉自旋标记成像(3D-ASL)及OEF序列扫描,观察脑梗死区域的氧摄取分数(OEF)、静脉血容量百分数(vCBV)、可逆性横向驰豫率(R2*)较对侧正常镜像区域的变化情况。结果:13例患者中,6例脑梗死区域OEF增加,其中4例vCBV、R2*增加,1例vCBV减低、R2'无明显变化,1例vCBV、R2*信号均无明显变化;7例脑梗死区域OEF减低,其中6例vCBV、R2*减低,1例vCBV增加、R2*无明显变化。结论:MRI-OEF序列有望应用于评估缺血性脑卒中患者的血流动力学变化及组织细胞氧代谢状态。Objective：To estimate the feasibility and application value of magnetic resonance oxygen extraction frac-tion imaging （MRI-OEF）in ischemic stroke.Methods：Thirteen patients with ischemic stroke were enrolled in this study. All subjects underwent DWI,3D-ASL,OEF,and routine magnetic resonance imaging （T1 WI、T2 WI、T2 FLAIR）scanning. The differences between ischemic region and the contralateral normal area in OEF、vCBV、R2 ＊ maps were observed.Results：Six of the thirteen patients showed high signal on OEF maps,four of the six demonstrated high signal on both vCBV and R2 ＊ maps,one demonstrated low signal on vCBV maps and normal on R2 ＊ maps,one looked normal in both vCBV and R2 ＊maps.Another seven patients showed low signal on OEF maps,of which six showed low signal on both vCBV and R2 ＊maps,the other one demonstrated high signal on vCBV maps and normal on R2 ＊ maps.Conclusion：MRI-OEF could be an additional method in evaluating the hemodynamic changes and assessing aerobic metabolism of cells in cerebral ischemic tis-sue,also it might have a great potential application in ischemic stroke.

关 键 词：磁共振成像 氧摄取分数成像 缺血性脑卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]