同源重组修复相关miRNAs在肿瘤中的研究进展  

Research progress of homologous recombination repairing related microRNAs in cancer

作　　者：喻晓娟[1] 卫彬[1] 吴晶晶[2] 高勇[1] 陈小飞[1] 

机构地区：[1]南京医科大学附属淮安第一医院肿瘤科,江苏淮安223300 [2]南京医科大学附属淮安第一医院血液科,江苏淮安223300

出　　处：《现代肿瘤医学》2015年第18期2694-2697,共4页Journal of Modern Oncology

基　　金：淮安市科技支撑计划资助项目(编号:HAS2011028)

摘　　要：同源重组(HR)作为DNA双链断裂损伤的主要修复机制,其功能异常可影响肿瘤对放疗及基因毒药物的敏感性并可为肿瘤个体化治疗提供生物标志物。微小核糖核酸(microRNAs,miRNAs)通过与mRNA的3'端非编码区结合来实现对靶基因的转录后调控。近年来研究发现miRNAs对同源重组修复通路也发挥着重要的调控作用,并影响肿瘤对放疗及基因毒药物的敏感性。本文对肿瘤中miRNAs调控HR修复通路的新进展进行综述。Homologous recombination （HR）served as the mainly repair pathway for DNA double strand breaks, which dysfunction could influence the sensitivity of radiotherapy and genotoxicity drugs.Presently,relevant clinical re-searches had confirmed the HR related gene or protein expression could be used as biomarkers for tumor individual-ized treatment.miRNAs （microRNAs）regulated the gene expression after transcription through combining the 3＇un -translated region of mRNA.In recent years,the studies found that miRNAs played an important role in regulating HR repair pathway and also affected the tumor -sensitivity for radiotherapy and genotoxicity drugs.This review summari-zes the recent new progress of miRNAs in regulation for homologous recombination repair pathway on cancer.

关 键 词：同源重组 微小核糖核酸 生物标志物 个体化治疗 

分 类 号：R730.5[医药卫生—肿瘤]