ERCC-1、BRCA-1和Survivin在非小细胞肺癌化疗患者中的表达及其与预后的相关性  

Expression of ERCC-1,BRCA-1 and Survivin and prognosis in non-small cell lung cancer and its prognostic relevance

作　　者：周彤[1] 刘燕文[1] 

机构地区：[1]连云港市第二人民医院内科,江苏连云港222023

出　　处：《中国肿瘤外科杂志》2015年第4期226-229,共4页Chinese Journal of Surgical Oncology

摘　　要：目的探讨以铂类、紫杉类为基础化疗方案的非小细胞肺癌患者中核苷酸切除修复交叉互补基因(ERCC-1)、乳腺癌敏感蛋白Ⅰ型(BRCA-1)、凋亡抑制基因(survivin)表达及其与预后的关系。方法采用免疫组化(IHC)检测74例以铂类、紫杉类为基础化疗的非小细胞肺癌患者组织标本中ERCC-1、BRCA-1及Survivin蛋白的表达,分析其表达与患者预后的关系。结果 (1)ERCC-1表达率60.81%,与患者性别、年龄、分期、病理及吸烟史无关,在化疗有效的患者中ERCC-1高表达率45.45%,在化疗无效的患者中高表达率83.33%(P=0.001)。(2)BRCA-1表达率59.46%,与患者性别、年龄、分期无关,与病理(0.016)及吸烟史(0.002)有关,在化疗有效的患者中BRCA-1高表达率47.33%,在化疗无效的患者中高表达率76.67%(P=0.016)。(3)Survivin表达率51.35%,与患者性别、年龄、分期、病理及吸烟史无关,在化疗有效的患者中Survivin高表达率40.91%,在化疗无效的患者中高表达率66.67%(P=0.035)。结论 ERCC-1、Survivin低表达,BRCA-1高表达患者能从含铂方案的化疗中获益,提示三者联合检测可以作为非小细胞肺癌患者化疗疗效的预测因素。Objective To investigate the relationship among expression of ERCC-1, BRCAI, Survivirl and prognosis in non-small cell lung cancer treated by platinum,Taxane-based chemotherapy. Methods The protein expression of ERCC-1, BRCA-1 and Survivin were detected by immunohistochemistry（IHC） in 74 patients. The relation between expression level of ERCC-1, BRCA-1, Survivin and prognosis was analyzed. Results （ 1 ） ERCC-1 expression rate was 60.81% , while gender, age, stage, pathology and history of smoking were irrelevant. The high expression rate of ERCC-1 was 45.45% in the patients reveiving chemo and 83.33% in the ineffective chemotherapy patients（ P = 0. 001 ）. （2）BRCA-1 expression rate was 59.46%, while gender, age, stage were irrelevant, but correlation with pathology and history of smoking were relevant. The high expression of BRCA-1 was 47.33% in the patients reveiving chemo and 76.67% in the ineffective chemotherapy patients （P = 0. 016）. （3）Survivin expression rate was 40.91%, while gender, age, stage, pathology and history of smoking were irrelevant. The high expression of Survivin was 40.91% in the chemotherapy patients and 66.67% in the ineffective chemotherapy patients（P = 0. 035 ）. Conclusions The expression rate of ERCC-1, BRCA-1 and Survivin may provide important predictive value for chemotherapy in non-small cell lung cancer.

关 键 词：ERCC-1 BRCA-1 Su^ivin 非小细胞肺癌 多西他赛 顺铂 

分 类 号：R734.2[医药卫生—肿瘤]