晚发型抑郁症伴轻度认知损害患者脑白质胆碱能通路的对照研究  

The White Matter Cholinergic Pathway in Late- onset Depression Patients with Mild Cognitive Impairment

作　　者：潘园园[1,2] 刘羽 孙剑[2] 李宁 

机构地区：[1]中国.江苏大学临床医学院,江苏镇江212013 [2]解放军102医院精神二科

出　　处：《中国健康心理学杂志》2015年第8期1121-1124,共4页China Journal of Health Psychology

摘　　要：目的：对伴轻度认知损害（ MCI）的晚发型抑郁症（ LOD）患者脑白质胆碱能通路的改变进行对照性研究，并分析其与患者认知功能各领域受损的关系。方法：对伴MCI的LOD患者（研究组，n＝25）磁共振成像的胆碱能通路高信号评分（ CHIPS），同时评定蒙特利尔认知评估量表（ MoCA），分析CHIPS评分与MoCA各认知领域的关系；并与不伴MCI的LOD患者（对照组，n＝25）进行对照。结果：①研究组MoCA总分、视空间与执行功能、延迟记忆、注意及工作记忆得分，均显著低于对照组，差异有统计学意义（t＝2．091～2．398，P＝0．041～0．028）；②研究组CHIPS显著高于对照组，差异有统计学意义（t＝2．097，P＝0．042）；③研究组CHIPS评分与MoCA总分、视空间与执行功能、延迟记忆得分显著负相关（r＝－0．434，－0．398，－0．483；P＜0．05）。结论：脑白质胆碱能通路受损，在LOD患者MCI的发生中可能起了一定的作用，尤其与其视空间与执行功能、记忆及延迟记忆的损害有关。Objective：To investigate the features of white matter cholinergic pathway impairment in late-onset depression（ LOD） with mild cognitive impairment（ MCI） and its relationship with the dysfunction of cognition.Methods：Twenty-five cases of LOD comorbidity MCI（ study group） and 25 LOD without MCI （ control group ） were scanned with cholinergic pathways hyperintensities scale （ CHIPS ） using MR and completed the Montreal cognitive assessment（ MoCA）.The relation between CHIPS and MoCA was analyzed.Results：①Participants in study group scored lower in total MoCA,visual space and execu-tive abilities,attention and working memory,delayed memory than that in the control group（ t=2.091～2.398,P〈0.05）.②The results of CHIPS were significant higher in LOD patients with MCI than those without（t =2.097,P=0.042）.③In correlation analysis,negative relationships were showed between CHIPS and scores of total MoCA, visual space and executive abilities, delayed memory （ r =-0.434,-0.398,-0.483;P〈0.05）.Conclusion：The results indicate that the cholinergic pathway impairments imply the pathogeny of MIC in LOD,especially the lesions of visual space and executive abilities or delayed memory.

关 键 词：抑郁症 老年人 胆碱能纤维 脑白质病变 轻度认知损害 

分 类 号：R749.4[医药卫生—神经病学与精神病学]