吸烟与肝癌发病风险的Meta分析  

A meta-analysis on association of cigarette smoking and the risk of hepatoceilular carcinoma

作　　者：龚杰[1] 虞颖映[2] 舒畅[2] 奚莱蕾[2] 马凌飞[2] 朱益民[1] 

机构地区：[1]浙江大学医学院流行病与卫生统计学教研室,杭州310031 [2]浙江省医学科学院情报研究所,杭州310013

出　　处：《国际流行病学传染病学杂志》2015年第4期250-255,共6页International Journal of Epidemiology and Infectious Disease

基　　金：浙江省科技计划（2013F50018）

摘　　要：目的探讨吸烟与肝癌发病的关系，为肝癌防治提供科学依据。方法制定原始文献的纳入和排除标准及检索策略，检索中国期刊全文数据库（CNKI）、中文科技期刊数据库（维普）、中国生物医学文献数据库、万方数据库、Pubmed、EMBASE、WebofScience、CochranceLibrary等数据库，收集关于吸烟与肝癌发病风险的相关研究。提取所需的数据和相关资料，并根据不同的吸烟量、吸烟现状进行分层分析。应用Statal2．0软件对各研究的结果进行Meta分析。结果最终纳入29篇研究吸烟与肝癌关系的病例对照文献，合并后的OR值为1．58（95％CI：1．47∽1．70）；共有7篇队列研究纳入Meta分析，合并后的RR值为1．49（95％C1：1．38∽1．60）。吸娴量≥20包年人群合并后的OR值为1．51（95％C1：1．33∽1．72）。戒炯和现在吸烟的人群合并后的OR值分别为1．39（95％CI：1.21—1．59）和1．50（95％C1：1．37—1．65）。结论吸烟与肝癌间存在病冈学联系，是肝癌发生的危险因素之一，且随着吸烟量的增加肝痛发病的风险也会增加。Objective To discuss the relation between cigarette smoking cmd hepatocellular carcinoma and provide scientific basis for the prevention and treatment. Methods Electronic search strategy was carried out among the databases from home and abroad to collect qualified research papers according to the inclusion and exclusion criteria. CNKI, VIP Chinese Periodical Database, Chinese BioMedical Literature Database, Wanfang Chinese Periodical Database, Pubmed （Medline）, EMBASE, Web of Science and Cochrance Library were searched for the case-control studies of cigarette smoking associated with hepatocellnlar carcinoma. The sub-group analysis was performed based on the different smoking frequency and different smoking status. The software Statal2.0 were used to do meta analysis. Results A total of 29 case-control studies were related to smoking and hepatocellular carcinoma, of which the combined OR was 1.58（95%CI：1.47-1.70）. Seven cohort studies were included to the meta analysis, and the RR was 1.49 （95%CI：1.38-1.60）. The combined OR for the individuals exposed to ≥20 pack- years smoking was 1.51 （95%CI：1.33-1.72）. The combined OR for the individuals quitted smoking and kept on smoking were 1.39 （95%CI：1.21-1.59） and 1.50 （95%CI：1.37-1.65）, respectively. Conclusions There is etiology relationship between smoking and hepatocellular carcinoma. Smoking is one of the risk factors to hepatocellular carcinoma. The onset risk of liver cancer will increase by the increasing of smoking amount.

关 键 词：肝肿瘤:吸烟 META分析 

分 类 号：R735.7[医药卫生—肿瘤]