尼莫地平对高血压脑出血患者脑血肿、水肿及神经功能恢复的影响  

Influence of Nimodipine on restoration of cerebral haematoma,edema and neurological function of patients with hypertensive cerebral hemorrhage

作　　者：杨鹤云[1] 杨正宇[1] 张红莲[1] 罗晓惠[1] 

机构地区：[1]昆明市第一人民医院神经内科,云南昆明650011

出　　处：《中国医药科学》2015年第1期121-123,共3页China Medicine And Pharmacy

摘　　要：目的探讨尼莫地平对高血压脑出血患者血肿、水肿及神经功能恢复的影响。方法选择我院2013年1～12月收治的高血压脑出血患者84例,随机分为研究组和对照组,各42例,对照组患者给予传统脱水、止血、抗炎、降压治疗,研究组患者在对照组治疗的基础上给予尼莫地平治疗;全部患者治疗3周后进行CT检查,观察血肿及周围水肿带体积变化情况,比较治疗前后神经功能缺损评分改善情况,评价治疗效果。结果治疗后两组血肿体积、水肿体积较治疗前减小,神经功能缺损评分较治疗前降低,前后差异有统计学意义（P〈0.05）,但研究组血肿体积、水肿体积、神经功能缺损评分明显小（低）于对照组（P〈0.05）。研究组治疗总有效率明显高于对照组,差异有统计学意义（P〈0.05）。结论尼莫地平辅助治疗高血压脑出血能有效减轻血肿及周围水肿,促进神经功能的恢复,对提高治疗效果有积极作用,值得应用。Objective To investigate the influence of Nimodipine on restoration of cerebral haematoma,edema and neurological function of patients with hypertensive cerebral hemorrhage. Methods 84 case of patients with hypertensive cerebral hemorrhage in our hospital from January to December 2013 were randomly divided into research group and control group,42 cases in the control group were given conventional dehydration,hemostasis,anti-inflammatory,antihypertensive treatment,research group was given nimodipine treatment on the basis of control group. After three weeks treatment,all patients were given CT scan,cerebral haematoma and edema volume changes were observed,before and after treatment,neurological deficit scores were compared,and therapeutic effect of two groups were evaluated. Results After treatment,hematoma,edema volume and neurological deficit scores of two groups were decreased,the differences were significant（P 〈 0.05）.But the cerebral haematoma volume,cerebral edema volume,neurological deficit scores of research group were significantly smaller（lower）than the control group （P 〈 0.05）.The total efficiency rate of research group was significantly higher than control group,the difference was significant （P 〈 0.05）. Conclusion In treatment of hypertensive cerebral hemorrhage, nimodipine can effectively reduce cerebral hematoma ,edema volume,and can promote the restoration of neurological function,has positive role in improving the treatment effect,it is worth of application.

关 键 词：高血压脑出血 尼莫地平 血肿 水肿 神经功能缺损评分 

分 类 号：R743.34[医药卫生—神经病学与精神病学]