山莨菪碱联合乌司他丁对重症胰腺炎大鼠模型的应用价值  

Application value of high doses of anisodamine combined with ulinastatin in the treatment of rats with severe acute pancreatitis

作　　者：黎永胜[1] 

机构地区：[1]汕头大学医学院第一附属医院急诊科,广东汕头515041

出　　处：《中国医药科学》2015年第7期27-28,42,共3页China Medicine And Pharmacy

摘　　要：目的探讨大剂量山莨菪碱联合乌司他丁治疗重症胰腺炎(SAP)的效果。方法取健康成年大鼠90只,依据随机数字表法分为对照组1(SAP组)、对照组2(SAP+乌司他丁治疗组)和观察组(SAP+大剂量山莨菪碱+乌司他丁治疗组),每组各30只。结果采用大剂量山莨菪碱联合乌司他丁治疗的观察组SAP大鼠血清淀粉酶、磷脂酶A2及内毒素水平低于对照组,3d存活率(73.33%)明显高于对照组;对照组2血清淀粉酶、磷脂酶A2及内毒素水平明显低于对照组1(P<0.05)。结论大剂量山莨菪碱联合乌司他丁治疗SAP,能有效松弛Oddi括约肌,抑制蛋白酶反应,抑制炎性介质表达,延长SAP存活期。ObjectiveTo investigate the effects of high doses of anisodamine combined with ulinastatin in the treatment of severe acute pancreatitis （SAP）. Methods 90 healthy adult rats were divided into 3 groups according to random number table：the control group 1 （SAP）,the control group 2 （SAP rats treated by ulinastatin） and the observation group （SAP rats treated by ulinastatin and high doses of anisodamine）,30 rats in each group.Results The level of serum amylase,phospholipase A2 and endotoxin lower in the observation group using high doses of anisodamine combined with ulinastatin than that in the control group,the survival rate on the third day was 73.33%,was significantly higher than that in the control group.The level of serum amylase,phospholipase A2 and endotoxin significantly was lower the control group 2 than that in the control group 1 （P〈0.05）.Conclusion The high dosage of anisodamine combined with ulinastatin on SAP,can effectively loose sphincter of Oddi,inhibit the protease reaction,inhibit the expression of inflammatory mediators, prolong the survival period of SAP.

关 键 词：重症胰腺炎 山莨菪碱 乌司他丁 存活率 

分 类 号：R576[医药卫生—消化系统]