PPAR-γ基因Pro12Ala多态性与非酒精性脂肪性肝病易感性的Meta分析  

Association between the Pro12Ala polymorphism of PPAR-γ gene and the susceptibility of non-alcoholic fatty liver disease: a Meta-analysis

作　　者：张少君[1] 董小林[1] 

机构地区：[1]湖北医药学院附属人民医院健康体检中心,湖北十堰442000

出　　处：《胃肠病学和肝病学杂志》2015年第8期913-916,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨PPAR-γ基因Pro12Ala多态性与非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)易感性的关系。方法检索Pub Med、Web of Science、万方数据库、中国知网(CNKI)、维普数据库,检索时间为建库至2014年8月30日,收集关于PPAR-γ基因Pro12Ala多态性与NAFLD易感性的病例-对照研究,采用Rev Man 5.2和Stata 12.0软件进行Meta分析。结果最终纳入8个病例-对照研究,包括1 697例病例和2 427名对照。其中5篇研究涉及亚洲人群,3篇涉及白种人群。Meta分析结果显示:PPAR-γ基因Pro12Ala多态性的基因型分布在病例组与对照组中差异无统计学意义(P>0.05),基于种族的亚组分析也得到相同结果。结论 PPAR-γ基因Pro12Ala多态性与NAFLD的易感性无明显相关性。Objective To investigate the association between Prol2Ala polymorphism of PPAR-γ gene and the sus- ceptibility of non-alcoholic fatty liver disease （NAFLD）. Methods All eligible case-control studies published up to Aug. 2014 were identified by searching PubMed, Web of Science, Wanfang, CNKI and VIP. Meta-analysis was calcu- lated by RevMan 5.2 and Stata 12.0 software. Results A total of 8 case-control studies were selected, including 1 697 cases and 2 427 controls. There were 5 studies on Asian populations and 3 on Caucasian populations, the results showed that there was no significant difference in genotype distribution of the Prol2Ala polymorphism of PPAR-γ gene between NAFLD and controls in all genetic models, meanwhile, similar results were observed in both Asian and Caucasian popu- lations. Conclusion The Pro12Ala polymorphism of PPAR-γ gene is not associated with the susceptibility of NAFLD.

关 键 词：PPAR-Γ 非酒精性脂肪性肝病 基因多态性 META分析 

分 类 号：R575.5[医药卫生—消化系统]