非酒精性脂肪性肝病患者血清瘦素水平与多种指标的临床相关性研究  

The clinical correlation between serum leptin levels and a variety of indicators in patients with non-alcoholic fatty liver disease

作　　者：阎雪燕[1] 张川[1] 

机构地区：[1]首都医科大学附属北京朝阳医院西区消化内科,北京100043

出　　处：《胃肠病学和肝病学杂志》2015年第8期920-922,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)患者血清瘦素水平与多种指标的临床相关性。方法选取首都医科大学附属北京朝阳医院2013年1月-2014年1月200例NAFLD患者,选择同期进行健康体检者100名,对两组的一般资料、生化检测、血清瘦素进行检测。结果 NAFLD患者的血清瘦素水平为(2 852.21±2 011.48)μg/L,健康体检者为(1 527.32±1 592.58)μg/L,两者比较,差异有统计学意义(t=10.482,P<0.05)。单因素分析显示NAFLD患者的瘦素水平与年龄、体质量、腰围、臀围、FBG、TP、ALB、UA、TG、TC、LDL-C、ALT、AST具有相关性(P<0.05)。Logistic回归分析NAFLD患者的臀围和LDL-C与血清瘦素水平呈正相关性(P<0.05)。结论 NAFLD患者的血清瘦素水平明显高于健康体检者,血清瘦素水平与LDL-C、臀围呈正相关。Objective To investigate the clinical correlation between serum leptin levels and a variety of indicators in patients with non-alcoholic fatty liver disease （NAFLD）. Methods Two hundred patients with NAFLD were chosen from Jan. 2013 to Jan. 2014 in Beijing Chaoyang Hospital Affiliated to Capital Medical University as the NAFLD group and 100 healthy people were as the control group. The general information, biochemical tests, serum leptin were detec- ted in two groups. Results Serum leptin level in NAFLD group was （2 852.21 ± 2 011.48） μg/L, the control group was （ 1 527.32± 1 592.58） μg/L, the difference was statistically significant （ t = 10. 482, P 〈 0.05）. Univariate anal- ysis showed that leptin was correlated with age, body mass, waist, hip, FBG, TP, ALB, UA, TG, TC, LDL-C, ALT, AST in NAFLD patients （P 〈 0.05）. Logistic regression analysis showed hip and LDL-C were positively correlated with leptin in NAFLD （P 〈0.05）. Conclusion The serum leptin level in the NAFLD patients is higher than that in the healthy people, and the serum leptin is positively correlated with the hip and LDL-C.

关 键 词：非酒精性脂肪性肝病 血清瘦素水平 指标 

分 类 号：R575.5[医药卫生—消化系统]