炎症性肠病的凝血功能研究  

The research of coagulation function in patients with inflammatory bowel disease

作　　者：汪亮[1] 何莉[1] 

机构地区：[1]成都市第七人民医院消化内科,四川成都610041

出　　处：《胃肠病学和肝病学杂志》2015年第8期946-949,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的比较炎症性肠病(inflammatory bowel disease,IBD)患者与健康人群之间的凝血功能差异。方法研究纳入51例IBD患者为试验组,26名健康人作为对照组。检测受试者血浆凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、抗凝血酶Ⅲ(AT-Ⅲ)、纤溶酶原、纤维蛋白原、D-二聚体、凝血因子V、凝血因子Ⅷ、蛋白C、蛋白S、活化蛋白C抵抗(APCR)。结果 2例UC患者有血栓史。试验组PT、凝血因子V、凝血因子Ⅷ、纤溶酶原、血小板计数均显著高于对照组,而蛋白C、蛋白S、纤溶酶原、血小板水平与疾病活动度、IBD分类密切相关。结论 IBD凝血功能异常为疾病进程继发性改变,且可能是多因素共同作用的结果。Objective To compare the difference of coagulation function between patients with inflammatory bowel disease （IBD） and healthy subjects. Methods Fifty-one patients with IBD and 26 healthy subjects were included in this study. Plasma levels of AT-Ⅲ, PT, APTT, D-dimer, plasminogen, fibrinogen, factor Ⅴ , factor Ⅷ, protein S, protein C, and activated protein C resistance （APCR） were examined. Results Two patients with ulcerative colitis had a history of previous thromboembolic event. Levels of PT, blood coagulation factor Ⅴ, blood coagulation factor Ⅷ, plate- let count and plasminogen were significantly higher in IBD patients than those in healthy subjects. The levels of protein C, protein S, plasminogen and platelet level were associated with the types of the disease （ Crohn＇ s disease or ulcerative colitis） and disease activity. Conclusion The coagulation abnormalities appears secondary to the disease progress, re- suiting from a multitude of factors.

关 键 词：炎症性肠病 克罗恩病 溃疡性结肠炎 凝血功能 

分 类 号：R574.62[医药卫生—消化系统]