10年间溃疡性结肠炎住院患者临床特征和治疗方式演变  

Ten- year Evolution of Clinical Features and Treatment Methods of Inpatient With Ulcerative Colitis

作　　者：雷晓燕[1,2,3] 崔梅花[1,2] 马志琳 戴立娜 

机构地区：[1]航天中心医院 [2]北京大学航天临床医学院消化科,北京市100049 [3]武汉市普仁医院消化科

出　　处：《中国全科医学》2015年第23期2856-2859,共4页Chinese General Practice

摘　　要：目的：探讨过去10年间溃疡性结肠炎（ UC）住院患者临床特征和治疗方式的演变。方法通过航天中心医院病案管理系统收集2003年1月—2012年12月住院诊断为UC患者的临床资料，记录患者一般资料、临床特征（临床类型、疾病分期、严重程度及病变范围）、治疗方式。比较前5年（2003—2007年）和后5年（2008—2012年）患者一般资料、临床特征和治疗方式的演变。结果共纳入115例患者，发病高峰年龄段分别为20～29岁（17例，占14.8％）及50～69岁（52例，占45.2％）。前5年纳入患者49例，后5年纳入患者66例，前、后5年患者病程比较，差异有统计学意义（Z＝-2.522， P＜0.05）。115例患者临床类型以初发型为主，占55.6％（64／115）；疾病分期多处于活动期，占93.9％（108／115）；严重程度以轻、中度为主，占81.5％（88／108）；病变范围以广泛结肠型为主，占51.3％（59／115）。115例患者均行内科药物治疗，其中应用氨基水杨酸制剂者97例（84.3％），包括单用水杨酸偶氮磺胺吡啶（SASP）者33例（28.7％），单用5-氨基水杨酸（5-ASA）者55例（47.8％）， SASP＋5-ASA者9例（7.8％）；局部保留灌肠者80例（69.6％）。前、后5年患者微生态制剂、止泻药使用率和局部保留灌肠治疗率比较，差异有统计学意义（χ2＝4.000、3.997、4.054， P＜0.05）。结论20～29岁及50～69岁是UC的发病高峰年龄段，初发型、轻中度活动期、广泛结肠型多见，病变范围呈扩大化，氨基水杨酸制剂仍是治疗UC的主要药物，微生态制剂、局部保留灌肠逐渐应用于治疗。Objective To study the evolution trend of clinical features and treatment methods of hospitalized patients with ulcerative colitis （ UC） last 10 years.Methods A retrospective study was performed to investigate the general situation , clinical characteristics （ clinical type , disease stage , severity degree and extent of disease ） , and treatment methods of 115 inpatients with UC in Aerospace Central Hospital from January 2003 to December 2012.Compare the general situation , clinical characteristics and treatment methods between first five years （ 2003—2007 ） and latter five years （ 2008—2012 ） . Results There were a total of 115 cases included in the study.The age ranges of morbidity peak included 20-29 （n=17, 14.8%）, 50-69 （n=52, 45.2%）.There were 49 cases included in first five years and 66 in latter five years.The patients included in the first five years were significantly different in the course of disease with those whom included in latter five years （ Z=-2.522, P＆lt;0.05）.Among 115 patients, most were initial （55.6%, 64/115）, active stage （93.9%, 108/115）, mild and moderate （81.5%, 88/108） and extensive colonic （51.3%, 59/115）.All the 115 patients were administrated with internal medicine , among which 97 patients （ 84.3%） applied aminosalicylic acid preparation , 33 patients （ 28.7%） applied SASP only , 55 patients （47.8%） applied 5-ASA, 9 patients （7.8%） applied SASP ＋5-ASA, and 80 patients （69.6%） applied local retention enema.The patients included in the first five years were significantly different （χ2 =4.000, 3.997, 4.054, P 〈0.05） from those included in the latter five years in the usage rate of microecologics , antidiarrheal and local retention enema . Conclusion The age ranges of morbidity peak are 20 -29 and 50 -69.The cases are mainly first onset , mild and moderate actively stage and extensive colitis .The extent of lesion show an increasing trend in 10 years.Amino salicylic acid is still the primary medication in t

关 键 词：结肠炎  溃疡性 住院病人 临床演变 回顾性研究 数据说明  统计 

分 类 号：R574.62[医药卫生—消化系统]