低氧微环境相关因子HIF-1α与癌症的研究  

Study on Related Factor HIF-1α in Hypoxic Microenvironment and Cancer

作　　者：余平[1,2] 刘晓旺[1] 钟丽菲[1] 丁维珂 陆凯强 周志刚[3] 涂剑[1] 

机构地区：[1]南华大学药物药理研究所,药物蛋白质组学湖南省高等学校重点实验室,湖南衡阳421001 [2]湖南环境生物职业技术学院医药学院,湖南衡阳421001 [3]南华大学附属第一医院,湖南衡阳421001

出　　处：《湖南生态科学学报》2015年第2期52-56,共5页Journal of Hunan Ecological Science

基　　金：湖南省自然科学基金青年项目(编号:2015JJ3101);衡阳市科技局课题(编号:2013KJ22)

摘　　要：环境与癌症的发生密切相关.低氧微环境主要受缺氧诱导因子-1α(HIF-1α)调控.近年研究表明,低氧微环境HIF-1α可在癌症中高表达,参与癌细胞的生长繁殖、侵袭/迁移、新血管生成和细胞凋亡等过程.研究主要围绕肝癌、乳腺癌和胃癌等与HIF-1α的关系进行讨论.参32.The environment is closely related with the occurrence of cancer. Hypoxic microenvironment is mainly regulated by Hypoxia-inducible factor-let （HIF-lct）. In recent years ,studies have shown that in hypoxia environment,HIF-1α could be abundantly expressed in many kinds of cancer,involved with the growth,invasion/migration, angiogenesis and apoptosis process of cancer cells. This article is mainly discussed around the relationship between HIF - 1α and cancer such as liver cancer,breast cancer and gastric cancer. 32refs.

关 键 词：低氧微环境 缺氧诱导因子-1Α 肝癌 乳腺癌 胃癌 

分 类 号：R73-3[医药卫生—肿瘤]