超氧化物歧化酶治疗放射性食管损伤的临床疗效观察  

An Observation on Clinical Effect of Superoxide Dismutase on Radioactive Esophageal Injury

作　　者：徐海亭[1] 张涛[1] 沈曼曼[1] 杨恕宁 张旭光[1] 

机构地区：[1]徐州市肿瘤医院放射治疗科,徐州221005

出　　处：《数理医药学杂志》2015年第9期1293-1295,共3页Journal of Mathematical Medicine

摘　　要：目的：探讨超氧化物歧化酶对放射性食管损伤的临床价值.方法：选取某院2010年1月-2014年10月收治的80例胸部肿瘤患者,随机分组观察研究.观察组：应用超氧化物歧化酶;阴性对照组：应用生理盐水;阳性对照组：应用康复新.观察对比各组临床疗效.结果：80例患者均顺利完成治疗.观察组严重程度显著低于阴性及阳性对照组（χ^2=9.552,P =0.004）;观察组食管反应主要出现在40-60Gy,放射损伤耐受剂量明显高于对照组（P =0.015,t=8.49）.结论：超氧化物歧化酶能有效减轻和推迟胸部肿瘤放射性食管损伤的发生,有效减轻患者痛苦,提高生活质量,保证放疗的顺利进行.Objective:To explore the clinical value of superoxide dismutase (SOD)to radioactive esopha-geal injury.Methods:Select 80 patients with chest tumor received in some hospital during the period from January 2010 to October 2010 ,group them randomly and make observation on them.the observation group were treated with superoxide dismutase while the negative control group were treated with saline and the positive control group applied kangfuxin.Observe and compare the clinical curative in each group.Results:All the 80 patients finished the treatment successfully .The severity of the observation group was significantly inferior to that of the positive and the negative control group (χ2=9.552,P=0.004);esophageal reaction mainly occurred in observation group when dose ranging within 40-60 Gy ,the tolerated dose of radioactive injury was significantly higher than that in control group (P=0.015,t=8.49).Conclusion:Superoxide dismu-tase can effectively weaken and and postpone the breakout of radioactive esophageal inj ury of chest tumor ,ef-fectively alleviate patients'suffering,improve their quality of life,and ensure radiotherapy can go on smooth-ly .

关 键 词：超氧化物歧化酶 放射性食管损伤 疗效 

分 类 号：R734[医药卫生—肿瘤]