草酸艾司西酞普兰合并艾地苯醌对脑卒中后抑郁的临床疗效观察  

Clinical observation of escitalopram oxalate combined with idebenone in treatment of post- stroke depression

作　　者：施玉梅[1] 许小梅[1] 李淑芬[1] 孙红杰[1] 郝翠杰[1] 韩秋利[1] 霍绪平[1] 

机构地区：[1]河北省荣军医院,保定071000

出　　处：《四川精神卫生》2015年第4期336-338,共3页Sichuan Mental Health

摘　　要：目的探讨草酸艾司西酞普兰合并艾地苯醌治疗脑卒中后抑郁的效果及安全性。方法将符合《国际疾病分类(第10版)》(ICD-10)脑卒中后抑郁症诊断标准的47例患者随机分为研究组(n=25)和对照组(n=22),给予研究组草酸艾司西酞普兰合并艾地苯醌治疗,给予对照组草酸艾司西酞普兰治疗。分别于治疗前和治疗后第1、2、3月采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、简易精神状态量表(MMSE)及副反应量表(TESS)评定疗效和不良反应。结果治疗前两组HAMD、HAMA、MMSE评分差异均无统计学意义(P>0.05),治疗3个月后研究组HAMA和HAMD评分低于对照组,MMSE评分高于对照组,研究组总有效率(84.00%)高于对照组(59.09%),差异均有统计学意义(P<0.05)。结论草酸艾司西酞普兰合并艾地苯醌治疗脑卒中后抑郁的效果优于单独应用草酸艾司西酞普兰。Objective To study the efficacy and safety of escitalopram oxalate combined with idebenone in treatment of post-stroke depression. Methods 47 patients with post- stroke depression which met the diagnostic of ICD- 10 were randomly divided into study group( n = 25) and control group( n = 22). The study group were treated with escitalopram oxalate combined with idebenone,and the control group were treated with escitalopram oxalate alone. Before the treatment and at 1,2 and 3 months after treatment,Hamilton Depression Scale( HAMD),Hamilton Anxitey Scale( HAMA),Mini- Mental State Examination( MMSE) and Treatment Emergent Symptom Scale( TESS) were used to assess the efficacy and security. Results Before the treatment,the scores of HAMD,HAMA and MMSE in the study group were not different from that in the control group( P > 0. 05). After the treatment for 3 months,the scores of HAMD,HAMA and MMSE were significantly improved both in the two group when compared with those before the treatment. The improved scores were significantly better in the study group than that in the control group( P < 0. 05). The total efficiency rate in the study group( 84%) was significantly higher than that in the control group( 59. 09%)( P < 0. 05). Conclusion Escitalopram oxalate combined with idebenone in treatment of post- stroke depression is more effective than escitalopram oxalate alone.

关 键 词：艾地苯醌 草酸艾司西酞普兰 脑卒中后抑郁 

分 类 号：R749.4[医药卫生—神经病学与精神病学]