网络成瘾者在不同情绪面孔刺激下的持续注意任务事件相关电位与治疗转归的相关性  

Relationship of treatment outcome with different emotion face stimulus on sustained attention activity relevant potential in patients with Internet addiction disorder

作　　者：宋来云 黄淑燕 向锋[1] 郑小泳 肖攀攀[3] 黄金焕[1] 梁雪玲[1] 李艳容[1] 徐伏莲[1] 

机构地区：[1]江门市第三人民医院精神科,529000 [2]广州市民政局精神病院,510430 [3]广州市精神病医院,510370

出　　处：《四川精神卫生》2015年第4期358-363,共6页Sichuan Mental Health

基　　金：江门市科技计划项目(2014020)

摘　　要：目的探讨不同情绪面孔刺激下网络成瘾(IAD)者执行持续注意任务时的事件相关电位特征,并分析其与治疗转归的相关性。方法选取符合网络成瘾临床诊断标准的38例网络成瘾者(研究组,IAD组)及性别、年龄、受教育年限与之相匹配的38例健康志愿者(对照组),在喜(愉悦)、怒(愤怒)、悲(悲伤)、恐(恐惧)4种情绪面孔刺激随机呈现后执行注意与选择任务,同时记录事件相关电位,观察IAD组治疗干预前后及对照组在4种情绪面孔诱发的N170电位及靶刺激诱发的P300电位的特征。采用中文网络成瘾量表(CIAS)、家庭功能评定量表(FAD)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评定网络成瘾严重程度和IAD组治疗效果。比较IAD组治疗干预前后及与对照组间的事件相关电位的差异与特征,分析其与治疗效果(量表)的相关性。结果1IAD组治疗前在4种情绪面孔刺激下颞枕区N170波幅均低于对照组[如恐惧面孔,(17.5±16.7)μv vs.(25.8±13.4)μv,P<0.05],顶枕区P300潜伏期均长于对照组[如恐惧面孔,(452.6±50.3)ms vs.(426.7±28.4)ms,P<0.05]。IAD组在4种情绪面孔刺激下诱发的N170波幅和潜伏期差异均无统计学意义(P均>0.05);诱发的P300在4种情绪面孔刺激中以恐惧面孔刺激后执行注意任务的P300波幅最低,潜伏期最长。2IAD组干预后在4种情绪面孔刺激下诱发的N170和P300波幅和潜伏期与对照组比较差异均无统计学意义(P均>0.05)。3在4种情绪面孔刺激下诱发的N170波幅与量表评分呈负相关,P300潜伏期与量表评分呈正相关;N170潜伏期、P300波幅与量表评分无显著相关性。结论网络成瘾者在4种情绪面孔刺激下以恐惧面孔刺激诱发的P300波幅最低、P300潜伏期最长;经治疗好转,N170波幅及P300潜伏期恢复到正常水平,N170波幅与疗效呈正相关,P300潜伏期与疗效呈负相关。Objective To study the characteristics of brian potential evoked by different emotion faces during sustained attention tasks in patients with internet addiction disorder( IAD) between before and after the treatment,and to analyze the correlation with treatment effect. Methods 38 patients met with the clinical diagnostic criteria for Internet addiction formulated( IAD group) before and after treatment and 38 healthy volunteers matched with sex,age and education( control group) were asked to fulfill the assignment after they were presented with 4 faces of joy,anger,sadness,fear and relative portal would been recorded. Then the N170 potentials evoked by emotion faces and P300 potentials evoked by target stimulus of the subjects were observed in the control group and IAD group before and after treatment. The Chinese Internet Addiction Scale( CIAS),Family Assessment Device( FAD),HAMD,HAMA were used to determine the internet addiction severity of tow groups and the curative efficacy of IAD group. To compare the characteristics of event related potentials between before and after treatment in IAD group,and compared with the control group,and the correlation analysis were performed between them and the treatment effect( scale). Results 1The specific N170 wave amplitudes in the temporal occipital stimulated by emotion faces were smaller in patients with IAD before treatment than in the controls [e. g. fear faces,( 17. 5 ±16. 7) μv vs.( 25. 8 ± 13. 4) μv,P < 0. 05]. The P300 latencies in parietal occipital stimulated by emotion faces were longer in patients with IAD before treatment than in the controls [e. g. fear faces,( 452. 6 ± 50. 3) ms vs.( 426. 7 ± 28. 4) ms,P < 0. 05].There were no significant difference in evoked N170 amplitude and latency among different emotion faces,and the smallest P300 amplitude and the longest P300 latency were found in patients with IAD before treatment during the sustained attention tast to the fear faces.2There were no significant difference in evoked amplitudes and latencies of N17

关 键 词：网络成瘾 情绪面孔 持续注意 事件相关电位 治疗转归 

分 类 号：R749[医药卫生—神经病学与精神病学]