功能性消化不良药物治疗的比较研究  

Clinical Study of Functional Dyspepsia Treatment with Mosapride or Teprenone

作　　者：李凤英[1] 徐卫东 徐亚茹[3] 房芳[1] 李爱文[4] 王新立[5] 

机构地区：[1]邹城市中医院 [2]中石化管道公司邹城输油处卫生所 [3]邹城市第一中学,山东邹城273500 [4]济宁医学院附属医院,山东济宁272129 [5]徐州医学院附属医院,江苏徐州221006

出　　处：《辽宁医学院学报》2015年第4期22-25,共4页Journal of Liaoning Medical University (LNMU) Bimonthly

摘　　要：目的比较使用莫沙比利和替普瑞酮对FD患者的治疗效果。方法前瞻性临床比较研究与随机分配在进行的试验。1 042例呈现FD症状的胃胀或上腹部疼痛的患者被录取。初始内镜评价后,使用莫沙比利5 mg tid或替普瑞酮替普瑞酮胶囊50 mg tid开始治疗。评估上腹疼和腹胀的严重程度和频率,健康相关的生活质量(HR-QOL),和病人的对药物依从性。结果在研究的1 027名患者中经内窥镜检查90例(9%)有器质性病变。在那些用内窥镜检测没有任何特定的病变,开始药物治疗前,264例(30%)胃肠道症状在一个星期之内消除。618仍有症状的患者被随机使用莫沙比利(n=311)或替普瑞酮(n=307)治疗。经两周的治疗,莫沙比利相比替普瑞酮有显著疗效。莫沙比利也改善HR-QOL,62%的病人喜欢用莫沙比利治疗,而只有27.6%的病人接受替普瑞酮治疗。结论为改善FD症状用内镜检查病人是有用的。在莫沙比利和替普瑞酮的安全性和有效性上比较,患者更愿意接受前者。Objective To compare the clinical efficacy of mosapride and teprenone in treating patients with functional dyspepsia （FD）. Methods This is a prospective clinical comparative study with randomized allocation trials. 1 042 patients with symptoms of FD, either gastric stasis （GSS） and/or epigastric pain （EPS）, were selected. After initial endoscopic evaluation, patients took ei- ther mosapride 5 mg tid or teprenone 50 mg tid. Severity and frequency of GSS and EPS, health - related quality of life （ HR - QOL） , and patients＇ compliance to medication were evaluated. Results Of the 1027 patients, organic lesions were found examined by en- doscopy in 90 patients （9%）. Among those without any specic lesions detected by endoscopy, gastrointes - tinal symptoms were re- solved within one week after the endoscopy in 264 （28%） patients before initiating medication. 618 patients who remained symptomat- ic were randomized to medication either with mosapride （n = 311 ） or teprenone （n = 307 ）. Compared with teprenone, two -week treatment with mosapride signi cantly improved GSS and EPS. Mosapride also improved HR - QOL. 62% of patients preferred to be treatment with mosapride, while only 27.6% of patients favored the treatment with teprenone. Conclusions Endoscopic examination proves to be useful in improving FD symptom. Patients prefer mosapride to teprenone for its safety and efficacy.

关 键 词：消化 治疗 研究 

分 类 号：R573.9[医药卫生—消化系统]