卡培他滨节拍化疗在晚期乳腺癌维持治疗中的疗效观察  

The Efficacy and Safety of Capecitabine Metronomic Chemotherapy as Maintenance Therapy in Patients with Metastatic Breast Cancer

作　　者：刘星[1] 薛海鸥[1] 

机构地区：[1]辽宁医学院附属第一医院肿瘤科,辽宁锦州121001

出　　处：《辽宁医学院学报》2015年第4期81-83,共3页Journal of Liaoning Medical University (LNMU) Bimonthly

摘　　要：目的探讨复发转移乳腺癌联合化疗后继续卡培他滨节拍化疗维持治疗的疗效及安全性。方法对64例复发转移性乳腺癌患者,6~8周期联合化疗后疗效评价无疾病进展,根据治疗方法不同分为节拍化疗组、常规化疗组和对照组。节拍化疗组23例给予小剂量卡培他滨节拍化疗500 g、2次/日,持续口服;常规化疗组21例给予卡培他滨1 250 mg/(m2·次)、2次/日,连续14 d,休7 d,21 d为1周期;对照组20例未予特殊治疗。4周期后观察疗效及毒副反应。结果疗效方面,客观缓解率节拍化疗组13.0%,常规化疗组19.0%,(P<0.05),肿瘤控制率节拍化疗组82.6%,常规化疗组85.7%,(P>0.05);毒副反应方面,节拍化疗组III^IV度骨髓抑制、消化道反应、手足综合征发生率均低于常规化疗组。结论卡培他滨维持治疗能使晚期复发转移性乳腺癌患者临床受益,小剂量节拍式维持治疗与常规剂量维持治疗控瘤效果相当,且毒副反应低、可耐受。Objective To evaluate the efficacy and safety of capecitabine metronomic chemotherapy as the maintenance therapy in the treatment of metastatic breast cancer （MBC）. Methods 64 cases were selected for the study, who had recurrent metastatic breast cancer （MBC） and received 6 to 8 cycles of combination chemotherapy without disease progression, and they were randomly di- vided into metronomic chemotherapy group, conventional chemotherapy group and control group. For the metronomic chemotherapy group （ n = 23 ） , patients were continuously given capecitabine 500mg twice daily. The conventional chemotherapy group （ n = 21 ） first received capecitabine 1250 mg/m2 twice a day for 14 days, and then took a break for 7 days. The treatment cycle was 21 days. For the control group （ n = 20） , no treatment was given. Efficacy and toxicity were observed after 4 cycles of treatment. Result The response rate in metronomic chemotherapy group was 13.0% and that in the conventional chemotherapy group was 19.0%. The disease control rate in metronomic chemotherapy group was 82. 6% and in conventional chemotherapy group was 85.7% , （P 〉 0. 05 ）. As for toxicity reaction, the metronomic chemotherapy group was lower than the conventional chemotherapy group in the myelosuppression rate of Grade Ⅲ-Ⅳ, gastroenteric reaction and hand - foot syndrome. Conclusion Capecitabine metronomic chemotherapy, with its clini- cal efficacy comparable to conventional chemotherapy and better tolerance and fewer adverse reactions, is applicable for the treatment of metastatic breast cancer as maintenance treatment.

关 键 词：转移性乳腺癌 卡培他滨 节拍化疗 维持治疗 

分 类 号：R737.9[医药卫生—肿瘤]