肿瘤微环境与肿瘤相关巨噬细胞的相互影响  

Interaction Between Tumor Microenvironment and Tumor- associated Macrophages

作　　者：孙静[1] 杨江华[1] 

机构地区：[1]皖南医学院弋矶山医院感染性疾病科,安徽芜湖241001

出　　处：《辽宁医学院学报》2015年第4期107-110,共4页Journal of Liaoning Medical University (LNMU) Bimonthly

基　　金：国家自然科学基金主任基金(81141083);安徽省高校省级自然科学研究项目(KJ2014A271)联合资助

摘　　要：肿瘤组织中浸润的巨噬细胞是肿瘤间质的重要组成部分。肿瘤区域特殊的微环境除了改变巨噬细胞表型及功能外,还与巨噬细胞的募集密切相关,而一旦肿瘤相关巨噬细胞被募集后,会进一步参与肿瘤细胞生长、血管形成、侵袭正常组织及远处转移等。因此,我们将肿瘤微环境与肿瘤相关巨噬细胞之间的关系进行总结。Infiltrated Macrophages in tumor tissues are important parts of the stroma｜ compartment. Special microenvironment of tumor region can not only change the phenotypes and function of macrophages, but also closely related to the recruitment of macropha- ges. Once the tumor associated maerophages were raised, tumor cell growth, angiogenesis, invasion and metastasis of normal tissues will be further involved. Therefore, this study reviews the correlation between tumor microenvironment and TAMs.

关 键 词：肿瘤 微环境 肿瘤相关巨噬细胞 细胞因子 

分 类 号：R730.2[医药卫生—肿瘤]