拷贝数变异在畜禽中的研究进展  

Research progress of copy number variation in livestock and poultry

作　　者：刘雪雪[1] 王月月[1] 董坤哲[1] 潘建飞[2] 赵谦[1] 马月辉[1] 

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193 [2]甘肃农业大学动物科技学院,兰州730030

出　　处：《黑龙江畜牧兽医》2015年第8期55-57,共3页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金项目(31272403;31472064);国家绒毛产业技术体系(CARS-40-01)

摘　　要：拷贝数变异(Copy number variation,CNV)是基因组结构变异(Structural variation,SV)的重要组成部分,主要指大小从1 kb到数Mb的DNA片段拷贝数改变,表现为亚显微水平的缺失和重复。有人先后应用不同的方法构建了畜禽的全基因组CNV图谱,并发现与色素沉积、表型性状和疾病相关的CNVs。为了更清楚地了解CNV这种结构变异,文章对近几年畜禽的CNV研究进行了较为全面的分析与阐述,结果表明:CNV分布有一定的保守性,其覆盖的序列约占基因组的30%,可用于畜禽基因组结构特征研究。Copy number variation （CNV） is an important component of genomic structural variation （ SV）, mainly refers to the changes in the copy number of the DNA fragments in the size from 1 kb to several Mb, and shows the deletions and duplications at a submicroscopic level. The ditterent methods have been applied to build the CNV map of the whole genome from livestock and poultry in domestic species genomc in succes- sion, and the copy number variations （CNVs） associated with pigmentation, phenotypic traits as well as the diseases have been also found. The article more comprehensively analyzes and elaborates the CNV studies in recent years in order to more dlearly know the structural variation. The results show that the distribution of CNV in livestock and poultry is conservative, and the CNV covered sequence accounts for about 30% of the genome, which can be used to study genomic structural characteristics in livestock and poultry.

关 键 词：拷贝数变异 畜禽 CNV图谱 表型变异 研究进展 

分 类 号：Q78[生物学—分子生物学]