甲基苯丙胺及海洛因依赖者认知功能损伤的特征  

THE CHARACTERISTIC OF COGNITIVE FUNCTION OF THE METHAMPHETAMINE ADDICTS AND THE HEROIN ADDICTS

作　　者：孙海明[1] 钟娜[1] 徐定 江海峰[1] 赵燕 杜江[1] 李传威 赵敏[1] 

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海200030 [2]上海市戒毒管理局,上海200080

出　　处：《中国药物依赖性杂志》2015年第4期257-261,共5页Chinese Journal of Drug Dependence

基　　金：十二五科技支撑计划(2012BAI01B07);国家自然科学基金(81271468);上海市卫生系统新百人计划(XBR2011015);上海市精神卫生中心院级课题(201103)

摘　　要：目的:本研究旨在了解甲基苯丙胺(methamphetamine,MA)依赖者及海洛因依赖者的认知功能特征。方法:研獉獉獉獉究招募38名MA依赖者、22名海洛因依赖者、32名健康对照,所有受试者完成计算机化的综合认知量表(CogS tate量表)测试,同时收集受试者人口学资料及药物滥用史。结果:在工作记忆任务、执行功能任务中,MA组的表现与海洛獉獉因组的任务表现无差异(P>0.05),但两组任务表现都差于健康对照组(P<0.05)。在言语记忆任务、认知情绪认知任务中,MA组表现差于海洛因组及健康对照组(P<0.05),但海洛因组与健康对照组无差异(P>0.05)。结论:MA獉獉依赖者及海洛因依赖者都存在工作记忆、执行功能损伤,但MA依赖者呈现更多领域的认知损伤(言语记忆、社会认知),提示两种物质依赖者认知功能损伤存在异同,将来需要开发具有针对性的物质依赖康复方法。Objective： This study aims at better understanding the characteristics of cognitive function of the methamphetamine addicts and the heroin addicts. Methods ： Thirty - eight MA addicts, 22 heroin addicts and 32 none - drug use healthy controls were recruited in our study, and all of them completed the computerized cognitive battery assessment battery （the CogState battery ）, and their demographic data and drug use history were collected. Results：In the tasks of working memory and executive function, the MA group and heroin group performed similarly （ P 〉 0.05 ）, but both of the groups performed worse than healthy control group （ P 〈 0.05 ）. In the tasks of verbal memory and cognitive emotional cognition, the MA group performed significantly worse than heroin group and healthy controls（P 〈0.05）, and the heroin group and healthy control group performed similarly（P 〉 0.05）. Conclusion ： The MA addicts and heroin addicts showed similar impairments in domains of working memory and executive function, but MA addicts appeared more domains with cognitive impairments （verbal memory, social function ）, which imply there are similarities and differences in cognitive function between two group. There needs for tailored rehabilitation approaches for different substance addiction.

关 键 词：甲基苯丙胺 海洛因 物质依赖 认知功能 

分 类 号：R749.99[医药卫生—神经病学与精神病学]