胰癌患者癌组织的中期因子和血管内皮生长因子的表达及临床意义  

Expression and clinical significance of midkine and vascular endothelial growth factor in pancreatic tumor tissue

作　　者：白春侠 

机构地区：[1]辽宁省营口市中心医院病理科,辽宁营口115000

出　　处：《中国民康医学》2015年第16期60-61,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨胰癌患者的癌组织的中期胰腺肿瘤组织因子(MK)和血管内皮生长因子-C(VEGF-C)的表达及意义。方法:免疫组织化学S-P法检测胰癌患者的癌肿瘤组织内MK、VEGF-C。结果:胰癌患者癌组织的MK、VEGF-C阳性率均高于癌旁组织和慢性胰腺炎患者的胰组织(P<0.05),胰癌患者癌旁组织与慢性胰腺炎患者的胰组织对比(P>0.05)。胰癌患者癌组织的MK阳性率及VEGF-C阳性率均高于癌旁组织和慢性胰腺炎患者的胰组织(P<0.05);癌旁组织及慢性胰腺炎患者的胰组织的MK阳性率及VEGF-C阳性率对比,无差异(P>0.05)。结论:MK、VEGF-C是胰癌早期诊断、发展和转移的重要指标。Objective： To investigate expression and clinical significance of midkine and vascular endothelial growth factor-C （VEGF-C） in pancreatic tumor tissue. Methods： Immunohistochemical S-P method was used to detect MK and VEGF-C in the pan-creatic tumor tissues. Results： The positive rates of VEGF-C and MK in the pancreatic tumor tissue were higher than those of adjacent tissue of carcinoma and chronic pancreatitis tissue （P〈0. 05）, and the difference between the adjacent tissue of carcinoma and chronic pancreatitis tissue was not significant （P〉0. 05）. Conclusions： MK and VEGF-C are important indicators in the early diagnosis and judgment of occurrence, development and metastasis of pancreatic cancer.

关 键 词：胰肿瘤组织 中期胰腺肿瘤组织因子 血管内皮生长因子-C 

分 类 号：R735.9[医药卫生—肿瘤]