β-catenin和Galectin-3在宫颈癌组织中的表达及其临床病理学意义  

The Expression of β-catenin and Galectin-3 in Cervical Carcinoma and Its Clinical Pathological Significances

作　　者：吴和刚[1] 袁森辅 周开梅[1] 郭宇[1] 袁密[1] 董华菊 

机构地区：[1]宜宾市第一人民医院病理科,四川宜宾644000

出　　处：《华西医学》2015年第8期1452-1456,共5页West China Medical Journal

摘　　要：目的探讨β-catenin和Galectin-3蛋白在宫颈癌的表达及临床病理学意义。方法收集2010年1月-2013年6月间手术切除经病理证实为宫颈癌标本83例。采用免疫组织化学法检测83例宫颈癌组织、45例宫颈上皮内瘤变(CIN)及25例正常宫颈中β-catenin和Galectin-3的表达。结果 1在宫颈癌组织中β-catenin和Galectin-3阳性表达率分别为74.70%、81.93%,均显著高于CINⅠ、CINⅡ和正常宫颈组织(P<0.05);但在CINⅢ中的表达与在宫颈癌中的表达差异无统计学意义(P>0.05),三者合并后与宫颈癌比较差异有统计学意义(P<0.05)。2β-catenin蛋白的表达与患者年龄、肿瘤大小及病理类型无关(P>0.05),与组织学分级、国际妇产科联盟(FIGO)分期及淋巴结转移有关(P<0.05);Galectin-3蛋白的表达与患者年龄、FIGO分期、肿瘤大小及病理类型无关(P>0.05),与组织学分级及淋巴结转移有关(P<0.05)。3β-catenin和Galectin-3蛋白表达呈正相关(r=0.327,P=0.002)。结论宫颈癌组织中Galectin-3的高表达及β-catenin的高表达与宫颈癌的浸润、转移有关,并可能成为判断宫颈癌组织转移及预后的指标之一。Objective To investigate the expression of carcinoma and its clinical pathological significance. Methods January 2010 to June 2013. By immunohistochemical method, β-catenin and Galectin-3 protein in human cervical Eighty-three cervical specimens were collected from β-catenin and Galectin-3 expression of the 83 cases of cervical carcinoma, 45 cases of intraepithelial neoplasia （CIN） and 25 normal cervix tissue （control） were detected. Results The positive expression rate in cervical carcinoma of β-catenin and Galectin-3 was respectively 74.70% and 81.93%, which was significantly higher than that in intraepithelial neoplasia （ Ⅰ and Ⅱ ） and normal cervical tissue （P 〈 0.05）. Compared with cervical cancer, the expression of β-catenin and Galectin-3 in CIN Ⅲ had no statistical significance （P 〉 0.05）. The positive expression of β-catenin was significantly correlated with histological grade of cervical cancer tissue, International Federation of Gynecology and Obstetrics grade and lymph node metastasis （P 〈 0.05）. The positive expression of Galectin-3 was closely related to histological grade of cervical cancer tissue and lymph node metastasis （P 〉 0.05）. Both β-catenin and Galectin-3 expression had no relationship with other clinical pathological parameters, such as age of patients, tumor size and pathological pattern of tumor （P 〉 0.05）. β-catenin expression had significant positive correlation with that of Galectin-3 （r=0.327, P=0.002）. Conclusions The expression of Galectin-3 and β-catenin increases obviously and is associated with abnormal clinical parameters （invasion or metastasis） in patients with cervical cancer. Galectin-3 and β-catenin may act as cancer metastasis and prognostic indicators in these patients.

关 键 词：Β-CATENIN GALECTIN-3 宫颈癌 浸润 转移 

分 类 号：R737.33[医药卫生—肿瘤]