精神分裂症和双相障碍患者微小躯体异常比较  

Comparision of minor physical anomalies between patients with schizophrenia and bipolar disorder

作　　者：林鄞[1] 李烜[1] 郑朝盾[1] 杨婵娟[1] 张晓菲[1] 邓文皓[1] 李卓丽[1] 梁卉薇[1] 曹莉萍[1] 

机构地区：[1]广州市惠爱医院(广州市精神病医院,广州市脑科医院),510089

出　　处：《临床精神医学杂志》2015年第4期228-230,共3页Journal of Clinical Psychiatry

基　　金：广州市医药卫生科技项目(20131A011089);广东省科技计划项目(20130319c)

摘　　要：目的:探索精神分裂症(SZ)和双相障碍(BD)患者微小躯体异常(MPAs)及其差异。方法:采用爱丁堡利手量表、部分躯体异常量表及新增条目对126例SZ患者(SZ组)、117例BD I型患者(BD组)及120名正常对照者(NC组)进行评定;计算利手偏侧化系数(LI)。结果:LI显示3组均为右偏侧化,BD组最为明显,SZ组最弱,差异有统计学意义(P<0.01)。3组间内眼距、外眼距和右手第二指长度∶右手第四手指长度(2D∶4D)总体差异有统计学意义(P均<0.01)。内眼距SZ组最大,BD组次之;外眼距BD组明显大于其他两组;2D∶4D SZ组明显大于比其他两组;SZ组和BD组内眦赘皮率明显多于NC组。头顶漩涡位置NC组多偏右侧,SZ组和BD组多在中间;SZ组耳末粘附、尖耳和第一、二趾间隙过宽明显多于其他两组。结论:SZ和BD患者有较多MPAs,可能存在神经发育偏侧化异常。Objective： To explore the minor physical anomalies（ MPAs） and the difference between the patients with schizophrenia（ SZ） and bipolar disorder（ BD）. Method： One hundred and twenty-six SZ patients（ SZ group）,117 BD patients（ BD group） and 120 normal controls（ NC group） were assessed by Edinburgh handedness inventory,abnormal part of the body scale and new items. The laterality index（ LI） of each group was calculated. Results： LI showed that there was laterality of right side in all of the 3 groups,the most obvious was BD group,the weakest was SZ group; the difference was statistically significant. There were significant differences of inner canthal distance,outer canthal distance and the length of the second finger of right hand∶ length of the fourth finger of right hand（ 2D∶ 4D） among the 3 groups（ all P〈0. 01）. The longest inner canthal distance was SZ group and then was BD group. The outer canthal distance in BD group was significantly longer than the other 2 groups; 2D∶ 4D in SZ group was significantly greater than the other 2 groups. The whorl position on head was more on right side in NC group,and on middle in SZ and BD groups. Epicanthus rate in SZ and BD groups was significantly higher than NC group. The rates of adherent ear lobe,cuspidal and gap between first and second toes in SZ group were significantly higher than those in the other 2 groups. Conclusion： The MPAs exist in SZ and BD patients who may have abnormal neurodevelopmental partial lateralization.

关 键 词：精神分裂症 双相障碍 微小躯体异常 神经发育 

分 类 号：R749.4[医药卫生—神经病学与精神病学]