不同牙周状态下龈沟液中瘦素水平的比较  

Comparison of Leptin Levels in Gingival Crevicular Fluid of Different Periodontal Status

作　　者：刘崇武[1] 吴春芳[1] 骆凯[1] 王希[1] 陈超[1] 郑瑜谦[1] 

机构地区：[1]福建医科大学附属口腔医院修复科,福建福州350002

出　　处：《口腔医学研究》2015年第8期798-800,共3页Journal of Oral Science Research

基　　金：福建省自然科学基金计划项目(编号:2010J0101);福建省卫生厅青年科研课题(编号:2010-1-38)

摘　　要：目的:检测牙周健康者、慢性龈炎和慢性牙周炎患牙龈沟液中瘦素水平,为牙周炎的早期诊断提供客观指标。方法:选择牙周健康者、慢性龈炎和慢性牙周炎患者3组,治疗前记录牙周各项临床指标,并用Whatman1号滤纸收集颊侧近远中牙周袋内GCF采用ELISA检测瘦素含量;同时收集血清进行瘦素水平的检测。结果:3组中慢性牙周炎组龈沟液中瘦素水平与牙周健康者龈沟液中瘦素水平比较有显著差异(P<0.05),慢性牙周炎组龈沟液中瘦素水平与慢性龈炎龈沟液中瘦素水平及慢性龈炎组龈沟液中瘦素水平与牙周健康者龈沟液中瘦素水平比较均无显著差异;牙周健康者、慢性龈炎和慢性牙周炎患者血液中瘦素水平比较均有显著差异(P<0.05)。血中的瘦素与临床指标PLI(P<0.01,r=0.593)、PD(P<0.05,r=0.920)、BI(P<0.05,r=0.862)、AL(P<0.05,r=0.846)均相关;龈沟液中的瘦素与临床指标PLI(P<0.01,r=0.813)、PD(P<0.05,r=0.962))、BI(P<0.05,r=0.720、AL(P<0.05,r=0.946)均相关。结论:龈沟液中瘦素水平可能是反映牙周组织状况的一项较为客观的指标。Objective： To evaluate gingival crevicular fluid （GCF） leptin levels and their relationship with periodon- tal health and disease. Methods： Forty-two individuals were divided into three groups： healthy subjects, patients with chronic gingivitis and chronic periodontitis. For each subject, plaque index （PLI）, pocket depth （PD）, bleed- ing index （BI）, and attachment level （AL） values were recorded before and after treatment. GCF samples （by Whatman（R） 1 filter paper） and serum samples （by venipuncture） were respectively collected to determine the leptin levels using enzyme-linked immunosorbent assay （ELISA） kit. Results.. The lowest GCF leptin level was observed in subjects with chronic periodontitis, and statistically significant compared with healthy subjects （P〈0.05）. In contrast, the highest serum leptin concentration was obtained for subjects with chronic periodontitis. The PLI, PD, BI, and AL all showed significant correlations with leptin levels in GCF and serum （P〈0.05）. Conclusion： Leptin levels in GCF may be used as an objective indicator to evaluate periodontal status.

关 键 词：牙周炎 牙龈炎 龈沟液 瘦素 

分 类 号：R781.4[医药卫生—口腔医学]