氨磺必利和国产奥氮平治疗难治性精神分裂症疗效及安全性对比  

The Effect and Safety Contrast of Refractory Schizophrenia Cured by Amisulpride and Olanzapine Agent

作　　者：贾艳洁 李辉[2] 

机构地区：[1]新疆石河子绿洲医院精神科五科,832000 [2]新疆石河子绿洲医院精神科三科,832000

出　　处：《中国继续医学教育》2015年第21期177-178,共2页China Continuing Medical Education

摘　　要：目的：比较氨磺必利和国产奥氮平治疗难治性精神分裂症疗效及安全性。方法从我院2014年3月～2015年3月收治的精神分裂症患者中随机性抽取100例作为研究对象，并将其分为研究组和对照组，每组各50例。研究组患者给予氨磺必利治疗，对照组给予国产奥氮平治疗。使用阳性与阴性症状量表（PANSS）和副反应量表（TESS）比较两组患者治疗前后的疗效和不良反应。结果两组患者在治疗后的阳性症状分和阴性症状分较治疗前均有明显下降（P ＜0.05）；两组患者治疗后的 PANSS 评分无明显差异（P ＞0.05）；研究组与对照组不良反应发生率比较无明显差异（P ＞0.05）。结论氨磺必利与国产奥氮平在难治性精神分裂症的治疗上均有效，不良反应发生率低，患者依从性好。Objective To compare the clinical effects and safety contrast of refractory schizophrenia cured by amisulpride and olanzapine agent. Methods 100 patients who suffered from the refractory schizophrenia and who accepted treatments in our hospital from March 2014 to March 2015 were taken as the research objects, and these patients were randomly divided into the control group and the study group, with 50 patients in each group. In the study group, they were treated with the amisulpride glucose while in the control group, they were treated with the olanzapine agen. Then, the treatment effect and adverse reactions of these two groups of patients were compared with the positive and negative symptoms scale （PANSS） and the response scale （TESS）. Results After the treatment, the positive symptoms and the negative symptoms of the symptoms of these two groups of patients were significantly decreased than that before the treatment （P〈0.05）.In addition, after treatment, the PANSS score of two groups of patients had no significant difference （P〉0.05）. The adverse reaction rate between the study group and the control group had no significant difference （P〉0.05）. Conclusion The amisulpride and olanzapine agent in the treatment of refractory schizophrenia are effective, which the incidence of adverse reactions is low and the patient compliance is good.

关 键 词：氨磺必利 奥氮平 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]